June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Backscattering diameter on optical coherence tomography: a novel prognostic biomarker in idiopathic macular hole surgery
Author Affiliations & Notes
  • Stefano De Cillà
    Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Piemonte, Italy
    Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy
  • Alessandro Rabiolo
    Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Piemonte, Italy
    Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy
  • Andrea Govetto
    Aziende Socio Sanitarie Territoriale dei Sette Laghi, Varese, Lombardia, Italy
  • Paolo Fogagnolo
    Azienda Ospedaliera San Paolo, Milano, Lombardia, Italy
  • Stefano Ranno
    Aziende Socio Sanitarie Territoriale dei Sette Laghi, Varese, Lombardia, Italy
  • Mattia Marchetti
    Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Piemonte, Italy
  • Filippo Frerio
    Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Piemonte, Italy
  • Davide Wild
    Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Piemonte, Italy
  • Valentina Gatti
    Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy
  • Micol Alkabes
    Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy
  • Footnotes
    Commercial Relationships   Stefano De Cillà None; Alessandro Rabiolo None; Andrea Govetto None; Paolo Fogagnolo None; Stefano Ranno None; Mattia Marchetti None; Filippo Frerio None; Davide Wild None; Valentina Gatti None; Micol Alkabes None
  • Footnotes
    Support  NONE
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3647. doi:
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    • Get Citation

      Stefano De Cillà, Alessandro Rabiolo, Andrea Govetto, Paolo Fogagnolo, Stefano Ranno, Mattia Marchetti, Filippo Frerio, Davide Wild, Valentina Gatti, Micol Alkabes; Backscattering diameter on optical coherence tomography: a novel prognostic biomarker in idiopathic macular hole surgery. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To test the hypothesis that optical coherence tomography (OCT) backscattering is a prognostic biomarker in idiopathic macular hole (MH) surgery

Methods : Retrospective cohort study of patients undergoing successful pars plana vitrectomy with internal limiting membrane peeling and gas tamponade for idiopathic MH. Demographic, clinical, and OCT imaging variables were collected at the preoperative visit and last available follow-up visit. Two investigators graded the following OCT parameters: MH minimum diameter, MH base diameter, MH backscattering, and EZ and ELM status (absent vs. present). Factors associated with postoperative BCVA and delta BCVA (postoperative BCVA – preoperative BCVA) were investigated with univariable linear regression models.

Results : Thirty-eight eyes (36 patients) with a median (interquartile range [IQR]) follow-up of 9 (8-11) months were included (Table 1). The median BCVA ([IQR]) improved from 0.75 (1–0.6) logMAR preoperatively to 0.2 (0.6–0.1) logMAR at the last available postoperative follow-up visit (p<0.001). Preoperative MH minimum diameter (for a 10-µm increase, estimate [standard error (SE)]: 0.009 [0.003] logMAR, p=0.003), MH base diameter (for a 10-µm increase, 0.003 [0.001] logMAR, p=0.23), and MH backscattering (for a 10-µm increase, 0.008 [0.002] logMAR, p<0.001) were significantly associated with postoperative BCVA (Table 2). The proportion of variance explained was the highest for MH backscattering (R2:0.30), followed by minimum MH diameter (R2:0.21), and MH base diameter (R2:0.14). None of the study variables were associated with delta BCVA.

Conclusions : Preoperative OCT backscattering is associated with postoperative visual acuity in patients undergoing idiopathic MH surgery and may be a novel OCT prognostic biomarker.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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