June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Impact of reticular pseudodrusen on retinal sensitivity in age-related macular degeneration
Author Affiliations & Notes
  • Chang Ki Yoon
    Opthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • Un Chul Park
    Opthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • Taffeta Ching Ning Yamaguchi
    Boehringer Ingelheim International GmbH, Ingelheim, Rheinland-Pfalz, Germany
  • Rolf Herrmann
    Boehringer Ingelheim International GmbH, Ingelheim, Rheinland-Pfalz, Germany
  • Footnotes
    Commercial Relationships   Chang Ki Yoon None; Un Chul Park None; Taffeta Ching Ning Yamaguchi None; Rolf Herrmann None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2765. doi:
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      Chang Ki Yoon, Un Chul Park, Taffeta Ching Ning Yamaguchi, Rolf Herrmann; Impact of reticular pseudodrusen on retinal sensitivity in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2765.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the impact of reticular pseudodrusen (RPD) on macular sensitivity in intermediate age-related macular degeneration (iAMD)

Methods : Eyes having iAMD and total drusen area more than ETDRS circle O-2 (≥0.50 mm2) were included to control drusen quantity. Presence of RPD, presence of soft drusen and type of RPD (dot or ribbon) were determined through multimodal imaging including fundus photography, fundus autofluorescence, infrared reflectance image and optical coherence tomography. Retinal sensitivity was measured using MAIA microperimetry. Retinal sensitivity was compared according to the presence, type and location of RPD. Multiple regression analysis was performed with average retinal sensitivity as the dependent variable and with sex, age, dot type RPD, ribbon type RPD, macular involving RPD and soft drusen.

Results : Five hundred thirty eyes of 302 participants were included. Total average and mean outer ring sensitivity were significantly smaller in eyes having RPD Sensitivity (without RPD vs with RPD) was 21.21 (4.53) vs 19.75 (5.06), P = 0.003 in total average; 20.81 (4.63) vs 18.3 (5.57), P < 0.001 in outermost ring (S1); 21.74 (4.46) vs 20.14 (5.09), P = 0.001 in second outer ring (S2)). Average retinal sensitivity (with vs without macular involving RPD) was 21.05 (5.14) vs 19.69 (4.98), P = 0.007 in total; 20.45 (5.25) vs 18.14 (5.62), P<0.001 in S1 and 21.53 (5.01) vs 20.13 (5.03), P = 0.006 in S2. Total mean sensitivity was significantly smaller in ribbon type RPD than dot type (18.02 (6.49) vs 20.66 (4.13), P<0.001). Retinal sensitivity was decreased if patients were older and had RPD, especially ribbon type in multiple linear regression.

Conclusions : Eyes with RPD showed a reduced retinal sensitivity. Ribbon type RPD are possibly correlated to a larger decrease in retinal sensitivity than dot type RPD.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1 Average retinal sensitivity as to presence of macular involving RPD and type of reticular pseudodrusen (RPD)

Figure 1 Average retinal sensitivity as to presence of macular involving RPD and type of reticular pseudodrusen (RPD)

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