June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Assessment of Visual Photosensitivity with and without Light Filtering Lenses in Subjects with Traumatic Brain Injury
Author Affiliations & Notes
  • Shivam Patel
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Mariela C Aguilar
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Alex Gonzalez
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Rhiya Mittal
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Heather Ann Durkee
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Paula Andrea Sepulveda Beltran
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Gemayaret Alvarez
    Department of Physical Medicine and Rehabilitation, University of Miami School of Medicine, Miami, Florida, United States
  • Barry E Hurwitz
    University of Miami Department of Psychology, Coral Gables, Florida, United States
    Behavioral Medicine Research Center, University of Miami, Miami, Florida, United States
  • Byron L Lam
    Anne Bates Leach Eye Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Elizabeth Felix
    Department of Physical Medicine and Rehabilitation, University of Miami School of Medicine, Miami, Florida, United States
    VA Miami Healthcare System, Miami, Florida, United States
  • Anat Galor
    Anne Bates Leach Eye Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
    VA Miami Healthcare System, Miami, Florida, United States
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Shivam Patel None; Mariela Aguilar None; Alex Gonzalez None; Rhiya Mittal None; Heather Durkee None; Paula Sepulveda Beltran None; Gemayaret Alvarez None; Barry Hurwitz None; Byron Lam None; Elizabeth Felix None; Anat Galor None; Jean-Marie Parel None
  • Footnotes
    Support  Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences R&D (CSRD) I01 CX002015 (Dr. Galor), Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (Dr. Galor), Rehabilitation R&D (RRD) I21 RX003883 (Dr. Galor), Department of Defense Gulf War Illness Research Program (GWIRP) W81XWH-20-1-0579 (Dr. Galor) and Vision Research Program (VRP) W81XWH-20-1-0820 (Dr. Galor), National Eye Institute U01 EY034686 (Dr. Galor), R01EY026174 (Dr. Galor), R61EY032468 (Dr. Galor), U01EY034686 (Dr. Galor), NIH Center Core Grant P30EY014801 (institutional) and Research to Prevent Blindness Unrestricted Grant GR004596-1 (institutional), Florida Lions Eye Bank and the Beauty of Sight Foundation (Dr. Parel), Donations from: Drs. Harry W. Flynn Jr, Karl R. Olsen, Martha E. Hildebrandt, Raksha Urs, Aaron Furtado (Dr. Parel), NIH NEI – LRP (Drs. Aguilar and Durkee), Henri and Flore Lesieur Foundation (Dr. Parel).
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4236. doi:
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    • Get Citation

      Shivam Patel, Mariela C Aguilar, Alex Gonzalez, Rhiya Mittal, Heather Ann Durkee, Paula Andrea Sepulveda Beltran, Gemayaret Alvarez, Barry E Hurwitz, Byron L Lam, Elizabeth Felix, Anat Galor, Jean-Marie Parel; Assessment of Visual Photosensitivity with and without Light Filtering Lenses in Subjects with Traumatic Brain Injury. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4236.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of our study was to assess visual photosensitivity with and without light filtering lenses using the Ocular Photosensitivity Analyzer (OPA) in subjects who had suffered a Traumatic Brain Injury (TBI).

Methods : 28 healthy subjects (15 females and 13 males, age = 33.3±13.6) and 23 TBI subjects (6 females and 17 males, age = 41.3±13.2) were assessed for their visual photosensitivity thresholds (VPT) with and without light filtering lenses using the OPA (Aguilar et al. BOE 2018, 9(11): 5583-5596). Each subject completed twice a 5-trial series one month apart (V1 and V2). The initial trial was completed without any glasses (No Lens (NL)) and the next four trials were completed while wearing each of the plano lens (PL, no filter), blue-light blocking lens (BL), FL-41 (FL), and gray lens (GL) glasses.

Results : The mean VPTs for TBI subjects were NL 1.7±1.0 log lux at V1 and 1.5±0.9 log lux at V2 (ICC = 0.88); PL 1.6±1.0 log lux at V1 and 1.6±1.1 log lux at V2 (ICC=0.94); BL 1.7±1.0 log lux at V1 and 1.6±1.0 log lux at V2 (ICC=0.95); FL 1.8±1.1 log lux at V1 and 1.8±1.1 log lux at V2 (ICC=0.92); and GL 1.9±1.1 log lux at V1 and 1.7±1.1 log lux at V2 (ICC=0.90). The mean VPTs for healthy subjects were NL 2.5±0.8 log lux at V1 and 2.3±0.8 log lux at V2 (ICC = 0.92); PL 2.4±0.9 log lux at V1 and 2.3±0.8 log lux at V2 (ICC=0.91); BL 2.4±0.9 log lux at V1 and 2.4±0.8 log lux at V2 (ICC=0.94); FL 2.8±0.9 log lux at V1 and 2.8±0.8 log lux at V2 (ICC=0.92); and GL 2.8±0.9 log lux at V1 and 2.7±0.8 log lux at V2 (ICC=0.92). The test-retest reproducibility for all trials between visits had good reliability. The overall preliminary findings indicate the NL and the PL (control conditions) yielded comparable VPT values within the healthy and TBI subjects. Additionally, we found that FL and GL improved light tolerance in healthy and TBI subjects significantly, more than the NL, PL, and BL conditions, p<0.05.

Conclusions : The OPA VPT is a reliable measure to quantify light sensitivity. TBI subjects were more sensitive to light than healthy subjects, as noted by a lower VPT across all conditions. TheOPA can detect a treatment effect using light filtering lenses. FL and GL lenses were shown to increase VPT in control and TBI subjects, improving visual photosensitivity. However, FL is preferred to GL because of the dark adaptation that occurs in individuals with long-term use of GL.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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