June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Longitudinal Border Tissue Configuration Changes during Experimental High Myopia Development in Juvenile Tree Shrews
Author Affiliations & Notes
  • Mahmoud Tawfik KhalafAllah
    Vision Science Graduate Program, The University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Mustapha El Hamdaoui
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Preston A Fuchs
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Fred Nugen
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Alexander M Levy
    Department of Biomedical Engineering, University of Alabama at Birmingham, Alabama, United States
  • Brian C. Samuels
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Rafael Grytz
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Footnotes
    Commercial Relationships   Mahmoud KhalafAllah None; Mustapha El Hamdaoui None; Preston Fuchs None; Fred Nugen None; Alexander Levy None; Brian Samuels Heidelberg Engineering, GmbH, Code F (Financial Support); Rafael Grytz Heidelberg Engineering, GmbH, Code F (Financial Support)
  • Footnotes
    Support  NIH Grants R01-EY027759, R01-EY026588, P30 EY0039039; EyeSight Foundation of Alabama; Research to Prevent Blindness. We like to thank Heidelberg Engineering, GmbH (Heidelberg, Germany) for providing the Spectralis OCT2 at no cost.
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2858. doi:
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      Mahmoud Tawfik KhalafAllah, Mustapha El Hamdaoui, Preston A Fuchs, Fred Nugen, Alexander M Levy, Brian C. Samuels, Rafael Grytz; Longitudinal Border Tissue Configuration Changes during Experimental High Myopia Development in Juvenile Tree Shrews. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2858.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the border tissue (BT) configuration changes during experimental high myopia development in juvenile tree shrews.

Methods : Juvenile tree shrews were randomly assigned to two groups: binocular normal visual experience (n=18) and monocular -10D lens treatment to induce experimental high myopia (n=12) in one eye while the other eye served as control. Refractive and biometric measurements were obtained daily. Forty-eight radial optical coherence tomography B-scans through the center of the optic nerve head (ONH) were obtained weekly for six weeks. Anterior scleral canal opening (ASCO) and Bruch’s membrane opening (BMO) were manually segmented after nonlinear distortion correction of each B-scan. BT configurations were labelled as internally or externally oblique if the BMO position was more than 3 µm inside or outside the ASCO perimeter, respectively. Differences among groups were assessed using linear mixed models with a Bonferroni correction to maintain an appropriate Type I error rate.

Results : BT configuration showed significant group interaction with time (P<0.001), where the prevalence of internally oblique configuration gradually increased while the prevalence of externally oblique configuration gradually decreased in experimental high myopic eyes compared to both normal (P<0.0001) and control (P<0.0001) eyes (Figure 1). A significantly higher tendency of change from internally to externally oblique configuration was observed in the experimental high myopic eyes in four sectors: Nasal, Inferonasal, Inferior and Inferotemporal (P <0.005) (Figure 2).

Conclusions : Experimental high myopia leads to an asymmetric remodeling of the ONH tissues, where the BT configuration changes from internally to externally oblique in ONH sectors that are closest to the posterior pole (nasal in tree shrew). This asymmetric ONH remodeling during high myopia development may contribute to the increased risk of glaucoma later in life.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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