June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The effects of artificial tears on the tear film using a novel, high-resolution tear film imager: a pilot study
Author Affiliations & Notes
  • Isaac M Tessone
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Gal Antman
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Ophthalmology, Rabin Medical Center, Petah Tikva, Central, Israel
  • Hernan Rios
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Sofia Ahsanuddin
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Luis MuncharazDuran
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brent A Siesky
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Rebecca Kellner
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Paul A Sidoti
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Masako Chen
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Lukas Ritzer
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Emanuel Mordechaev
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Ethan Moy
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Toco Y. P. Chui
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Richard B Rosen
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Isaac Tessone None; Gal Antman None; Hernan Rios None; Sofia Ahsanuddin None; Luis MuncharazDuran None; Alice Chandra Verticchio Vercellin None; Brent Siesky None; Rebecca Kellner None; Paul Sidoti None; Masako Chen None; Lukas Ritzer None; Emanuel Mordechaev None; Ethan Moy None; Toco Chui None; Richard Rosen Optovue, Boehriger-Ingelheim, Code C (Consultant/Contractor), Topcon, Code F (Financial Support), Optovue, Guardion, Opticology, Code I (Personal Financial Interest), Optovue, Code P (Patent), Ocusciences, Topcon, Code R (Recipient), OD-OS, Code S (non-remunerative)
  • Footnotes
    Support  National Institutes of Health under award numbers R01EY027301 and R01HL159116; additional funding for this research was provided by the Marrus Family Foundation, Challenge Grant award from Research to Prevent Blindness, the Jorge N. Buxton Microsurgical Foundation, and the New York Eye & Ear Foundation.
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 194. doi:
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    • Get Citation

      Isaac M Tessone, Gal Antman, Hernan Rios, Sofia Ahsanuddin, Luis MuncharazDuran, Alice Chandra Verticchio Vercellin, Brent A Siesky, Rebecca Kellner, Paul A Sidoti, Masako Chen, Lukas Ritzer, Emanuel Mordechaev, Ethan Moy, Toco Y. P. Chui, Richard B Rosen; The effects of artificial tears on the tear film using a novel, high-resolution tear film imager: a pilot study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):194.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The objective of this study was to investigate the effects of different artificial tears (AT) on the sublayers of the tear-film (TF) using a novel tear film imaging device (TFI).

Methods : In this prospective pilot study, a single-nanometer resolution TFI (AdOM Ltd., Israel) was used to assess the TF muco-aqueous layer thickness (MALT) and lipid-layer thickness (LLT) in 7 treatment-naive subjects with mild Meibomian gland dysfunction, while exposed to three commercial brands of preservative-free AT: Allergan Refresh Plus® (REF), Ocusoft Retaine® (RTA), and Alcon Systane complete PF® (SYS). Each subject had the same eye imaged on three separate days using different AT. Each session consisted of a baseline TF measure, followed by measures at 1, 5, 10, 30, and 60 minutes after instilling one AT drop. The AT regimen was randomized to avoid an order effect. A Friedman Test was used for statistical comparisons with a p value < 0.05 considered significant.

Results : The median age of the study participants was 25 years (IQR: 25-31). Baseline MALT and LLT were found to be comparable between the AT groups (p=0.102 and p=0.867, respectively). There was a statistical difference between MALT measurements at different times among all 3 AT groups (REF: p=0.005, SYS: p=0.003, RTA: p=0.048). The median MALT was highest at 1 minute for all AT groups, with an increase of 63%, 14%, and 121% for REF, RTA, and SYS, respectively (Figure 1A). Moreover, when analyzing all MALT and LLT measurements, there were statistical differences between the AT groups (p<0.001 and p=0.004, respectively), with SYS demonstrating the greatest increases (Figure 1A, 1B). The duration of the effect of AT on the sublayers was between 1-60 minutes, with some measures not returning to baseline even after 1 hour (Figure 2A, 2B).

Conclusions : We report for the first time the effects of different AT on MALT and LLT on the human TF, using a high-resolution TFI. The results highlight the substantial increases in MALT after one minute and demonstrate that SYS had the largest impact on MALT and LLT. The results also suggest the need for tailoring specific AT to different individuals. A larger long-term study is needed to ascertain the role of the TFI in optimizing AT treatment.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Median MALT (1A) and LLT (1B) % change from baseline over 60 minutes

Median MALT (1A) and LLT (1B) % change from baseline over 60 minutes

 

MALT (2A) and LLT (2B) for each subject (S1-S7) at 60 minutes relative to baseline

MALT (2A) and LLT (2B) for each subject (S1-S7) at 60 minutes relative to baseline

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