June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Effect of repetitive transorbital alternating current stimulation (rtACS) on vision-related quality of life (QoL) in subjects with glaucoma
Author Affiliations & Notes
  • Ashley Sohn
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Maria de los Angeles Ramos Cadena
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • TingFang Lee
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York, United States
  • Jiyuan Hu
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York, United States
  • Bernhard Sabel
    Institute of Medical Psychology, Medical Faculty, Otto von Guericke Universitat Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
  • Rachel Matayev
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Heather Livengood
    Division of Occupational Therapy, West Virginia University, Morgantown, West Virginia, United States
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering and Electrical & Computer Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Joel S Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering and Electrical & Computer Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Footnotes
    Commercial Relationships   Ashley Sohn None; Maria de los Angeles Ramos Cadena None; TingFang Lee None; Jiyuan Hu None; Bernhard Sabel Savir GmbH (Berlin, Germany), Code C (Consultant/Contractor); Rachel Matayev None; Heather Livengood None; Gadi Wollstein None; Joel Schuman Zeiss, Code P (Patent)
  • Footnotes
    Support  P30EY013079; An unrestricted grant from Research to Prevent Blindness; NIH R01-EY013178
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4351. doi:
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    • Get Citation

      Ashley Sohn, Maria de los Angeles Ramos Cadena, TingFang Lee, Jiyuan Hu, Bernhard Sabel, Rachel Matayev, Heather Livengood, Gadi Wollstein, Joel S Schuman; Effect of repetitive transorbital alternating current stimulation (rtACS) on vision-related quality of life (QoL) in subjects with glaucoma. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4351.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : rtACS is an electrical neurostimulation treatment that delivers a weak periorbital electric current. It aims to enhance neuronal function from the retina to the visual system in the brain via the synchronization of neuronal network oscillations. The purpose of this double-masked, randomized, sham-controlled clinical trial study was to evaluate the effect of rtACS therapy on vision-related QoL in subjects with glaucoma.

Methods : Subjects with moderate to advanced glaucoma were randomized to rtACS or sham treatment for 10 consecutive days. All subjects completed the Visual Function Questionnaire (VFQ-39) at baseline, post-intervention (1 week) (PI) and follow-up (8 weeks) (f/u) visits. The VFQ-39 is divided into 11 vision-related domains and scores range from 0 (worst possible functioning) to 100 (best possible functioning). Subscale scores for each domain were calculated according to the VFQ-39 manual and the composite score was calculated as an unweighted average of the 11 subscale scores. A linear regression model was used to evaluate the difference in change in score from baseline to PI and from baseline to f/u between rtACS-intervention and sham groups with adjustment for baseline scores.

Results : Fifteen subjects were included in the study— 6 subjects were in the rtACS group and 9 in the sham group (Table 1). There was no significant difference between the two groups from baseline to PI for assessed QoL measures. The rtACS group showed a significantly larger improvement in score from baseline to f/u compared to the sham group in near activities, dependency and social functioning with subsequent improvement in mental health and the composite score (Table 2).

Conclusions : rtACS therapy showed a significant beneficial effect on several domains of quality of life even in our small pilot study. The study confirms previous observations that patients show greater benefits at f/u compared to PI testing, but the reason for this effect requires further investigation.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Table 1. Baseline characteristics.

Table 1. Baseline characteristics.

 

Table 2. Baseline scores and mean difference between treated versus control group in improvement in scores.

Table 2. Baseline scores and mean difference between treated versus control group in improvement in scores.

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