June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Assessment of increase in Omega -3 index with various nutritional supplements
Author Affiliations & Notes
  • Pinakin Gunvant Davey
    Optometry, Western University of Health Sciences, Pomona, California, United States
    Center for Clinical Research, Western University of Health Sciences, Pomona, California, United States
  • Cesar Ochoa
    Center for Clinical Research, Western University of Health Sciences, Pomona, California, United States
  • Edith Avita
    Center for Clinical Research, Western University of Health Sciences, Pomona, California, United States
  • Vrutti Mehta
    Optometry, Western University of Health Sciences, Pomona, California, United States
  • Stephanie Amonoo-Monney
    Optometry, Western University of Health Sciences, Pomona, California, United States
  • Frank Spors
    Optometry, Western University of Health Sciences, Pomona, California, United States
  • Footnotes
    Commercial Relationships   Pinakin Davey Guardion Health Sciences, Code C (Consultant/Contractor), Guardion Health Sciences, Code F (Financial Support); Cesar Ochoa None; Edith Avita None; Vrutti Mehta None; Stephanie Amonoo-Monney Guardion Health Sciences, Code C (Consultant/Contractor); Frank Spors None
  • Footnotes
    Support  Gaurdion Health Sciences Grant to WesternUniversity of Health Sciences (PGD)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 428. doi:
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    • Get Citation

      Pinakin Gunvant Davey, Cesar Ochoa, Edith Avita, Vrutti Mehta, Stephanie Amonoo-Monney, Frank Spors; Assessment of increase in Omega -3 index with various nutritional supplements. Invest. Ophthalmol. Vis. Sci. 2023;64(8):428.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
Abstract

Purpose : Various reports have shown numerous benefits of Omega-3 supplements on ocular health, particularly Dry Eye Syndrome and Age-Related Macular Degeneration. We sought to investigate the changes in various fatty acid levels in the red blood cells with intake of three commercially available Omega-3 supplements.

Methods : Ninety individuals who self-reported not consuming omega supplements were randomly assigned to one of three groups (Gummies, Softgels and OmegaBoost gel bites). The baseline fatty acid levels were measured, and omega-3 supplements were provided to participants who were instructed to take the supplements as directed by the manufacturer. The blood omega tests were repeated at a 4-, 8- and 12-week period and participants also completed survey about their general health and ocular health at each visit. The OmegaQuant labs Sioux Falls SD analyzed the blood samples to obtain omega-3 levels, omega-6 fatty acids, cis-Monounsaturated Fatty Acids, saturated fatty acids, trans fatty acids. Additionally, arachidonic acid to eicosapentaenoic acid ratio and omega 3 to omega 6 ratios were calculated. Eighty-six participants completed the study.

Results : The baseline, age and omega 3-index were not significantly different between group (Table 1). There was a significant effect of time/duration of consumption of omega 3 supplements (F(2,83)=24.02, p<0.001 see Table1). All mean differences among groups for the Omega 3 Index were significant. The Gummies versus Soft gel group indicated statistically significant mean differences -1.043, p <.001. The Soft Gel versus Omega Boost group showed statistically significant mean differences -0.887, p =.007 and the Omega Boost versus the Gummies showed statistically significant mean differences, 1.930, p <.001.

Conclusions : The intake of commercially available omega-3 supplements significantly improves the omega-3 levels in red blood cells. The mean improvement varies with the type of omega supplement consumed; with the Omega Boost gel bites providing a greater and faster increase of omega-3 index when compared to Gummies or Softgels. Patients should be educated on the level’s omega-3 when choosing omega-3 OTC supplements.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

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