June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
High-resolution wide-field single-shot panretinal imaging enabled by swept-source OCT angiography
Author Affiliations & Notes
  • Tristan Hormel
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Guangru Ben Liang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Xiang Wei
    Apple Inc, Cupertino, California, United States
  • Yukun Guo
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Min Gao
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Jie Wang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Steve Bailey
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Thomas S Hwang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Tristan Hormel None; Guangru Liang None; Xiang Wei None; Yukun Guo None; Min Gao None; Jie Wang Visionix/Optovue, Code P (Patent); Steve Bailey None; Thomas Hwang None; Yali Jia Visionix/Optovue, Code F (Financial Support), Visionix/Optovue, Optos, Code P (Patent)
  • Footnotes
    Support  This work was supported by grant National Institutes of Health (R01 EY027833, R01 EY024544, R01 EY031394, T32 EY023211, UL1TR002369, P30 EY010572); Unrestricted Departmental Funding Grant and Dr. H. James and Carole Free Catalyst Award from Research to Prevent Blindness (New York, NY); Bright Focus Foundation (G2020168).
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4422. doi:
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    • Get Citation

      Tristan Hormel, Guangru Ben Liang, Xiang Wei, Yukun Guo, Min Gao, Jie Wang, Steve Bailey, Thomas S Hwang, Yali Jia; High-resolution wide-field single-shot panretinal imaging enabled by swept-source OCT angiography. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4422.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the performance of a 500-kHz swept-source OCT angiography (OCTA) device and its ability to image pathology throughout the retina and choroid.

Methods : We imaged healthy eyes and eyes from multiple common disease types including age-related macular degeneration, diabetic retinopathy, and retinal branch vein occlusion using a 1050-nm central wavelength, 500-kHz swept-source OCTA prototype developed by our group (Fig. 1). This device includes several innovations that enable the capture of ultra-wide field images (up to 75 degrees, 12×23-mm) and images of both anterior and posterior regions of the retina as well as the choroid. These include small sample beam spot size (12 mm) on the retina to enable high-resolution, capillary scale imaging. Flow was detected using a highly-sensitive phase-stabilized complex-decorrelation approach that uses all the available information in the reflectance signal in order clearly visualize vessels with low flow speed. High-resolution OCTA images were further enhanced using a customized deep-learning-based capillary reconstruction method. Artifacts were minimized using a combination of hardware and software approaches, including reflectance-based volumetric projection artifact removal, a custom designed sample arm to avoid vignetting artifacts, and a self-navigated motion tracking system to avoid microsaccades and other image disrupting motion artifacts. Image quality was assured by generating real-time OCTA images using graphics processing units.

Results : We imaged 10 patients with branch retinal vein occlusions (example shown in Fig. 2), 95 patients with diabetic retinopathy, and 194 patients with age-related macular degeneration. Novel features of interest including choriocapillaris capillaries in the central macula and visual cortex hyalocyte cells above the inner limiting membrane can be readily observed in these images.

Conclusions : Swept-source OCTA with appropriate design consideration can produce high-quality images throughout the retina and choroid.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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