June 2023
Volume 64, Issue 9
Open Access
ARVO Imaging in the Eye Conference Abstract  |   June 2023
Motion correction and volume merging of ultrahigh resolution OCT enable 3D visualization and longitudinal tracking of hyperreflective foci
Author Affiliations & Notes
  • Jungeun Won
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Antonio Yaghy
    New England Eye Center, Boston, Massachusetts, United States
  • Stefan Ploner
    Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany
  • Hiroyuki Takahashi
    New England Eye Center, Boston, Massachusetts, United States
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Marcel Reimann
    Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany
  • Jessica M. Girgis
    New England Eye Center, Boston, Massachusetts, United States
  • Kenneth Lam
    New England Eye Center, Boston, Massachusetts, United States
  • Yunchan Hwang
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Siyu Chen
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Andreas Maier
    Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany
  • Nadia K. Waheed
    New England Eye Center, Boston, Massachusetts, United States
  • James G. Fujimoto
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Jungeun Won, None; Antonio Yaghy, None; Stefan Ploner, VISTA-OCTA (P); Hiroyuki Takahashi, None; Marcel Reimann, None; Jessica Girgis, None; Kenneth Lam, None; Yunchan Hwang, None; Siyu Chen, None; Andreas Maier, None; Nadia Waheed, AGTC (E), Complement Thrapeutics (C), Gyroscope (I), Hubble (C), Iolyx Pharmaceuticals (C), Nidek (F), Nidek (R), Ocudyne (I), Olix Pharma (C), Saliogen (C), Syncona (C), Topcon (C), Topcon (F), Zeiss (F); James Fujimoto, Optovue (I), Optovue (P), Topcon (F), VISTA-OCTA (P)
  • Footnotes
    Support  NIH Grant EY011289
Investigative Ophthalmology & Visual Science June 2023, Vol.64, PP0018. doi:
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      Jungeun Won, Antonio Yaghy, Stefan Ploner, Hiroyuki Takahashi, Marcel Reimann, Jessica M. Girgis, Kenneth Lam, Yunchan Hwang, Siyu Chen, Andreas Maier, Nadia K. Waheed, James G. Fujimoto; Motion correction and volume merging of ultrahigh resolution OCT enable 3D visualization and longitudinal tracking of hyperreflective foci. Invest. Ophthalmol. Vis. Sci. 2023;64(9):PP0018.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Hyperreflective foci (HRF) are associated with disease progression in age-related macular degeneration (AMD). While ultrahigh resolution optical coherence tomography (UHR OCT) with fine A-scan spacing may reveal HRF of smaller sizes, volumetric assessment and visualization are challenging. This study investigates visualization and detection of HRF in 3D using motion corrected, volume merged UHR OCT.

Methods : A spectral-domain UHR OCT prototype with ~2.7 μm axial resolution and 128 kHz A-scan rate was used to image early AMD patients at baseline and up to 1 year follow-up. Six raster scans with alternating fast-scan direction were acquired over 6 mm x 6 mm field-of-view and 12 µm isotropic A-scan spacing. Patient motion was computationally estimated and compensated in 3D, and volumes were merged to enhance SNR and continuity of features. The optical attenuation coefficient (OAC) was computed to generate en face HRF maps encoded with depth information. The en face maps of detected HRF were compared with 3D visualization, and overlaid on a retinal pigment epithelium (RPE) projection map. Longitudinal datasets were volumetrically registered and overlaid to highlight progression of HRF in cross-sectional B-scans.

Results : Motion corrected and merged volumetric UHR OCT enabled 3D visualization of HRF smaller than conventional HRF (viewed in an oblique plane indicated by white solid line in Figure 1). OAC-based detection algorithm generated en face HRF map showing relative depth position, which facilitated longitudinal tracking of HRF in a depth-resolved manner. Figure 1 shows representative increases in detected HRFs as well as changes in HRF positions (both in axial and transverse dimensions) at 1 year follow-up in an early AMD eye. Longitudinal changes of the HRF can also be visualized in 3D and cross-sectional B-scans. Displaying the detected HRF in en face map with depth information provides valuable insight into the distribution and directionality of migrating HRF and allows direct comparisons with outer retinal features.

Conclusions : Motion correction and volume merging using an isotropic scanning protocol and fine A-scan spacing in UHR OCT reveal smaller and thinner HRF in AMD patients, which can be detected and projected to en face map. This may provide a more sensitive marker of AMD and progression.

This abstract was presented at the 2023 ARVO Imaging in the Eye Conference, held in New Orleans, LA, April 21-22, 2023.

 

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