Abstract
Purpose :
To assess the repeatability and reproducibility of measures from the wide scan and standard macula/disc cube scans of a swept-source optical coherence tomography(SS-OCT) and a spectral-domain OCT(SD-OCT), and to evaluate the agreement of wide scan measures between the two devices, in normal and glaucoma eyes.
Methods :
Three DRI OCT Triton(SS-OCT) devices and Three 3D OCT-1 Maestro(SD-OCT) devices were employed. Each operator was paired with one Triton and one Maestro to create three operator/device configurations. Eligible subjects were randomized to select the study eye and testing order of the operator/device. All study eyes underwent wide scan(12×9mm) and standard disc/macula cube scans(6×6mm/7×7mm). At least 3 scans/eye were taken for each scan mode and each operator/device configuration. Parameter measurements included thickness of circumpapillary retinal nerve fiber layer(cpRNFL), ganglion cell layer(GCL)+inner plexiform layer(IPL)+RNFL(GCL++), and GCL+IPL(GCL+) from wide scans and cube scans. A two-way random effect analysis of variance(ANOVA) model, including the operator/device, eye, and interaction between operator/device and eye as the variance components, was used to estimate the repeatability and reproducibility limits, and coefficient of variation(CV%) for each scan parameter by group. Measurement agreement between wide scan measures of Triton and Maestro was evaluated by the Bland-Altman plots, 95% limits of agreement(LOA), and Deming regression for each group.
Results :
25 normal eyes and 25 glaucoma eyes were tested. The mean 24-2 mean deviation(MD) of glaucoma eyes was -5.30±6.77dB. Overall, the precision estimates were low(indicating high precision) for all measures with majority of the limits <5µm for macula measures and <10µm for disc measures. Precisions of the wide scan and cube scan were mostly similar in both groups with limit ratios around 1. Triton showed higher precision for many measurements. The measurement differences between the wide scan of the two devices were minor with the mean difference less than 3µm across all measures.
Conclusions :
Precision of thickness measures from wide scan and cube scans of SS-OCT Triton and SD-OCT Maestro in glaucoma eyes were high and comparable. Wide scan measurements of the SS-OCT and SD-OCT showed excellent agreement. These findings suggest promising potentials of wide scan for glaucoma management.
This abstract was presented at the 2023 ARVO Imaging in the Eye Conference, held in New Orleans, LA, April 21-22, 2023.