June 2023
Volume 64, Issue 9
Open Access
ARVO Imaging in the Eye Conference Abstract  |   June 2023
Comparison of microaneurysm detectability between MHz WF-OCTA and kHz WF-OCTA in advanced diabetic retinopathy
Author Affiliations & Notes
  • Kim Lien Huber
    Department of Ophthalmology and Optometry, Medical University of Vienna, Austria
  • Heiko Stino
    Department of Ophthalmology and Optometry, Medical University of Vienna, Austria
  • Thomas Schlegl
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
  • Michael Niederleithner
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
  • Wolfgang Drexler
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
  • Rainer A Leitgeb
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology and Optometry, Medical University of Vienna, Austria
  • Tilman Schmoll
    Carl Zeiss Meditec, Inc., Dublin, California, United States
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
  • Andreas Pollreisz
    Department of Ophthalmology and Optometry, Medical University of Vienna, Austria
  • Footnotes
    Commercial Relationships   Kim Lien Huber, Carl Zeiss Meditec, Inc. (C); Heiko Stino, None; Thomas Schlegl, Carl Zeiss Meditec, Inc. (C); Michael Niederleithner, Carl Zeiss Meditec, Inc. (C); Wolfgang Drexler, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (C); Rainer Leitgeb, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (C); Ursula Schmidt-Erfurth, None; Tilman Schmoll, Carl Zeiss Meditec, Inc. (E); Andreas Pollreisz, Carl Zeiss Meditec, Inc. (F)
  • Footnotes
    Support   Horizon 2020 Framework Program: H2020-ICT-2016-1, MOON grant no. 732969
Investigative Ophthalmology & Visual Science June 2023, Vol.64, PB0054. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kim Lien Huber, Heiko Stino, Thomas Schlegl, Michael Niederleithner, Wolfgang Drexler, Rainer A Leitgeb, Ursula Schmidt-Erfurth, Tilman Schmoll, Andreas Pollreisz; Comparison of microaneurysm detectability between MHz WF-OCTA and kHz WF-OCTA in advanced diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2023;64(9):PB0054.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare the difference in diabetic microaneurysm (MA) detection between an ultrafast megahertz (MHz) widefield optical coherence tomography angiography (WF-OCTA) device and a commercially available kilohertz (kHz) WF-OCTA device.

Methods : Patients with advanced diabetic retinopathy (DR) were recruited at the Department of Ophthalmology at the Medical University of Vienna for this cross-sectional study.
Multimodal imaging was performed on the same day, including imaging with a custom-built swept-source MHz WF-OCTA prototype (A-scan rate: 1.7 MHz; FOV: 18 mm in diameter) equipped with deep learning (DL) based 3D denoising, kHz WF-OCTA (A-scan rate: 200 kHz; FOV: 12x12 mm; PLEX® Elite 9000, ZEISS, Dublin, CA), fluorescein angiography (FA) and color fundus (CF) imaging (Optos®, Optos California). Microaneurysms (MAs) were manually evaluated on en face images by a human expert reader within an extended ETDRS grid consisting of a central 1 mm diameter disc, inner (IR, 0.5–1.5 mm), outer (OR, 1.5–3.0 mm) and extended ring (ER, 3.0 mm-6.0 mm).

Results : Thirty-four eyes of 34 patients with severe non-proliferative DR (n=11) and proliferative DR (n=23) were included in this study. A mean number of 160 ± 145 (± standard deviation) MAs per eye were detected from the gold standard FA images. MHz WF-OCTA and kHz WF-OCTA detected 55% and 44% of MAs, respectively. Significantly more MAs in total were detected on MHz WF-OCTA compared to kHz WF-OCTA (p=0.007). MHz WF-OCTA outperformed kHz WF-OCTA in MA detection in the outer (p=0.006) and the extended ETDRS ring (p=0.031). CF showed the lowest detection rate with 34% of MAs. Details of MA numbers in specific ETDRS rings are shown in Table 1.

Conclusions : MHz WF-OCTA in combination with DL-based image denoising techniques outperformed kHz WF-OCTA in the detection of diabetic MAs, which was pronounced in the extra-macular and peripheral regions of an extended ETDRS grid.

This abstract was presented at the 2023 ARVO Imaging in the Eye Conference, held in New Orleans, LA, April 21-22, 2023.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×