June 2023
Volume 64, Issue 9
Open Access
ARVO Imaging in the Eye Conference Abstract  |   June 2023
High resolution optical coherence tomography reveals details of regeneration after selective retina therapy
Author Affiliations & Notes
  • Chantal Dysli
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Christian Burri
    optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Bern, Switzerland
    Institute of Applied Physics, University of Bern, Biomedical Photonics Group, Bern, Bern, Switzerland
  • Simon Salzmann
    optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Bern, Switzerland
  • Boris Povazay
    optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Bern, Switzerland
  • Meier Christoph
    optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Bern, Switzerland
  • Frenz Martin
    Institute of Applied Physics, University of Bern, Biomedical Photonics Group, Bern, Bern, Switzerland
  • Martin S. Zinkernagel
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Sebastian Wolf
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Footnotes
    Commercial Relationships   Chantal Dysli, None; Christian Burri, Heidelberg Engineering (F), Heidelberg Engineering (R), Meridian Medical (F), Meridian Medical (R); Simon Salzmann, Heidelberg Engineering (R), Meridian Medical (R); Boris Povazay, None; Meier Christoph, None; Frenz Martin, None; Martin S. Zinkernagel, Bayer (C), Bayer (F), Boehringer Ingelheim (C), Novartis (C), Roche (C), Zeiss (C); Sebastian Wolf, Bayer (C), Bayer (F), Boehringer Ingelheim (C), EarlySight (C), Novartis (C), Novartis (F), Roche (C), Roche (F), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, PB0052. doi:
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      Chantal Dysli, Christian Burri, Simon Salzmann, Boris Povazay, Meier Christoph, Frenz Martin, Martin S. Zinkernagel, Sebastian Wolf; High resolution optical coherence tomography reveals details of regeneration after selective retina therapy. Invest. Ophthalmol. Vis. Sci. 2023;64(9):PB0052.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the course of retinal regeneration after selective retina therapy (SRT) using high-resolution spectral-domain optical coherence tomography (High-Res-OCT).

Methods : Imaging data origin from the CENTAURUS study. SRT was performed in patients with diabetic retinopathy using the SPECTRALIS CENTAURUS device (HuCE-optoLab, BFH-TI, Switzerland). SRT laser lesions were observed over a follow-up period of 6 months using High-Res-OCT (Heidelberg Engineering, Germany). High-Res-OCT enables imaging with increased axial resolution of up to 3 µm due to increased bandwidth of 130 nm (central wavelength: 840 nm) compared to conventional spectral-domain OCT devices (bandwidth: 40 nm, axial resolution 7 µm).

Results : Up to 90 laser lesions with different laser pulse energy in the retina of two subjects were analyzed over a follow-up period of six months. Laser lesions, especially those with higher laser pulse energy lead to an initial hyperreflectivity in the outer retinal layers, which disappeared within the first week. After one week, a local proliferation and hyperreflectivity on the level of the retinal pigment epithelium (RPE) was observed, which normalized over the course of six months. At the final visit, no remaining retinal changes after SRT laser were detectable using High-Res-OCT.

Conclusions : The increased axial resolution makes High-Res-OCT a great imaging tool for detection of subtle retinal changes after SRT, and for follow-up over time. SRT lesions especially lead to focal proliferation in the level of the RPE with regeneration over time without observation of permanent scar formation or induction of neovascularization.

This abstract was presented at the 2023 ARVO Imaging in the Eye Conference, held in New Orleans, LA, April 21-22, 2023.

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