In the Cox proportional hazards models, the presence of DH (model 1: hazard ratio [HR], 3.10; 95% CI, 1.34–7.18;
P = 0.008; model 2: HR, 2.86; 95% CI, 1.25–6.55;
P = 0.013), higher baseline IOP (HR, 1.23 per mm Hg; 95% CI, 1.07–1.41;
P = 0.003), and mean IOP during the follow-up period (HR, 1.30 per mm Hg; 95% CI, 1.04–1.64;
P = 0.024) were significant predictors of VF progression (
Table 2). DH (HR, 2.82; 95% CI, 1.29–6.18;
P = 0.010) and higher mean IOP (HR, 1.21 per mm Hg; 95% CI, 1.02–1.43;
P = 0.025) were also significantly associated with structural progression (GCIPL/RNFL progression) in patients with NTG, while older age (HR, 0.97 per year; 95% CI, 0.97–0.99;
P = 0.012) and higher minimum DBP (HR, 0.96 per mm Hg; 95% CI, 0.92–1.00;
P = 0.027) were identified as protective factors (
Table 3). Additionally, female gender (model 1: HR, 1.98; 95% CI, 1.08–3.62;
P = 0.027; model 2: HR, 2.27; 95% CI, 1.27–4.06;
P = 0.006), DH (model 1: HR, 2.82; 95% CI, 1.48–5.35;
P = 0.002; model 2: HR, 2.73; 95% CI, 1.44–5.15;
P = 0.002), and higher mean IOP (HR, 1.14 per mm Hg; 95% CI, 1.00–1.31;
P = 0.051) were associated with a higher risk of glaucomatous progression (defined as functional or structural progression,
Table 4). Current smoking (HR, 4.82; 95% CI, 1.10–21.10;
P = 0.037) was significantly associated with progressing by VF faster than −0.50 dB/y (
Table 5). Longer AL (HR, 0.57 per mm; 95% CI, 0.35–0.94;
P = 0.026) was protective against this fast progression.