Abstract
Purpose :
This study investigates the impact of retinal traction caused by epiretinal membranes (ERMs) on aniseikonia and retinal microstructures. The study quantifies retinal traction by assessing the maximum depth of retinal fold (MDRF) using en face Optical Coherence Tomography (OCT) images. Correlations between MDRF and aniseikonia, as well as OCT parameters are analyzed preoperatively and at the 6-month postoperatively.
Methods :
Eighty-one unilateral ERM patients participated. Retinal traction was quantified by visualizing retinal folds with en face OCT and measured the distance between the inner limiting membrane and the deepest point of the retinal fold (MDRF). Measurements included mean inner nuclear layer (INL) and outer plexiform layer (OPL) - outer nuclear layer (ONL) thickness, along with central retinal thickness (CRT), using B-scan OCT. The interocular ratios of the FAZ area in ERM eyes relative to those in fellow eyes were also calculated (FAZ ratio). The New Aniseikonia Test (NAT; Handaya, Tokyo, Japan) was employed to quantify the degree of aniseikonia.
Results :
Results:
A significant correlation was found between preoperative MDRF and preoperative NAT score (r = 0.487, P < 0.001, Figure), preoperative INL thickness (r = 0.562, P < 0.001), preoperative CRT (r = 0.588, P < 0.001), and preoperative FAZ ratio (r = -0.328, P = 0.003), excluding a significant correlation with preoperative OPL-ONL thickness (r = 0.214, P = 0.055). The preoperative NAT score significantly correlated with preoperative INL and OPL-ONL thickness (r = 0.524, P < 0.001 and r = 0.259, P = 0.020, respectively), and preoperative CRT (r = 0.331, P = 0.003), excluding a significant association with preoperative FAZ ratio (r = -0.328, P = 0.066). Multiple regression analysis revealed that preoperative NAT score was significantly associated with preoperative MDRF, INL, and OPL-ONL thickness (P = 0.029, 0.006, and 0.006, respectively). Twenty- nine eyes underwent vitrectomy and membrane peeling, resolving retinal all the retinal folds within the parafoveal area by 6 months postoperatively. A significant correlation was observed between preoperative MDRF and postoperative NAT score (r = 0.467, P = 0.011, Figure).
Conclusions :
Retinal traction induced by ERM is significantly associated with aniseikonia both pre- and post-surgery, as well as other OCT parameters.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.