Investigative Ophthalmology & Visual Science Cover Image for Volume 65, Issue 7
June 2024
Volume 65, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2024
The role of eye dominance and test order in studies of structured light entoptic phenomena
Author Affiliations & Notes
  • Mukhit Kulmaganbetov
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
    Glaucoma, Kazakh Eye Research Institute, Almaty, Kazakhstan
  • Benjamin Thompson
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
    School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada
  • Taranjit Singh
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
  • Andrew Ernest Silva
    School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada
  • Connor Lewis Kapahi
    Department of Physics, University of Waterloo, Waterloo, Ontario, Canada
    University of Waterloo Institute for Quantum Computing, Waterloo, Ontario, Canada
  • Melanie Mungalsingh
    School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada
  • David Cory
    Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
    University of Waterloo Institute for Quantum Computing, Waterloo, Ontario, Canada
  • Dmitry Pushin
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
    Department of Physics, University of Waterloo, Waterloo, Ontario, Canada
  • Dusan Sarenac
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
    Department of Physics, University at Buffalo, Buffalo, New York, United States
  • Footnotes
    Commercial Relationships   Mukhit Kulmaganbetov None; Benjamin Thompson None; Taranjit Singh None; Andrew Silva None; Connor Kapahi None; Melanie Mungalsingh None; David Cory None; Dmitry Pushin None; Dusan Sarenac None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 3058. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Mukhit Kulmaganbetov, Benjamin Thompson, Taranjit Singh, Andrew Ernest Silva, Connor Lewis Kapahi, Melanie Mungalsingh, David Cory, Dmitry Pushin, Dusan Sarenac; The role of eye dominance and test order in studies of structured light entoptic phenomena. Invest. Ophthalmol. Vis. Sci. 2024;65(7):3058.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Structured light (SL) perception is emerging as a promising tool for detecting early-stage age-related macular degeneration (AMD). We investigated the potential influence of eye dominance and order effects on SL perception, factors that could influence the sensitivity of screening tests based on SL technology.

Methods : Twenty-seven participants (mean age: 25 ± 5.5; female/male: 13/14) performed a psychophysical task to characterize the entoptic percept generated by polarized SL. The extent of the retina sensitive to polarization was quantified by adjusting a central occluding pattern designed to disrupt the entoptic percept according to a 2-down, 1-up staircase rule. Comprehensive eye and vision examinations were conducted, including visual acuity assessment, subjective refraction, binocular vision evaluation, ocular motility examination, interpupillary distance measurement, contrast sensitivity testing, slit-lamp biomicroscopy, indirect ophthalmoscopy, colour fundus photography, optical coherence tomography, ocular biometry measurement, and macular pigment optical densitometry.

Results : The mean diameter of the retinal area sensitive to SL polarization was 13.86 degrees for the dominant eye and 13.69 degrees for the non-dominant eye, with no significant interocular difference observed (Figure 1). Additionally, no order effect was observed for the second eye tested when comparing the order of eye testing. Statistical analysis (Wilcoxon rank-sum test) revealed no significant differences in various ocular health indicators between the two eyes of the participants.

Conclusions : Entoptic images induced by OAM-coupled polarized light hold potential for enhancing the detection and diagnosis of AMD. The absence of a relationship between SL perception and eye dominance, as well as the order of eye testing, indicates that these factors will not confound the results of SL-based screening and diagnostic tests.

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.

 

Figure 1. Top Left – Size of the central obstruction mask of the entoptic pattern (or diameter of the retinal area sensitive to SL polarization) in degrees for the dominant and non-dominant eyes; Top Right – Linear regression model between these eyes. Bottom Left – Size of the central obstruction mask of the entoptic pattern for the first and second eyes and their linear regression model (Bottom Right)

Figure 1. Top Left – Size of the central obstruction mask of the entoptic pattern (or diameter of the retinal area sensitive to SL polarization) in degrees for the dominant and non-dominant eyes; Top Right – Linear regression model between these eyes. Bottom Left – Size of the central obstruction mask of the entoptic pattern for the first and second eyes and their linear regression model (Bottom Right)

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×