Investigative Ophthalmology & Visual Science Cover Image for Volume 65, Issue 7
June 2024
Volume 65, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2024
Accommodative response is virtually paralyzed by temporal defocus waves
Author Affiliations & Notes
  • Victor Rodriguez-Lopez
    Consejo Superior de Investigaciones Cientificas, Madrid, Comunidad de Madrid, Spain
  • Paulina Dotor
    Consejo Superior de Investigaciones Cientificas, Madrid, Comunidad de Madrid, Spain
  • Carlos Dorronsoro
    Consejo Superior de Investigaciones Cientificas, Madrid, Comunidad de Madrid, Spain
    2EyesVision, Spain
  • Footnotes
    Commercial Relationships   Victor Rodriguez-Lopez CSIC, P190451ES, Code P (Patent); Paulina Dotor None; Carlos Dorronsoro CSIC, P190451ES, Code P (Patent)
  • Footnotes
    Support  LA Caixa Foundation ID100010434 LCF/BQ/DR19/11740032 & AEI grant CPP2021-008388
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 6310. doi:
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    • Get Citation

      Victor Rodriguez-Lopez, Paulina Dotor, Carlos Dorronsoro; Accommodative response is virtually paralyzed by temporal defocus waves. Invest. Ophthalmol. Vis. Sci. 2024;65(7):6310.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the lack of accommodative activation during the Direct Subjective Refraction (DSR) as a reason for its accuracy

Methods : DSR uses a tunable lens projected onto the pupil’s eye to induce periodic defocus changes at 15Hz and 0.25D of amplitude. Subjects minimize flicker perception on a bichromatic (red/blue) stimulus by varying the mean optical power. The position of the minimum flicker provides the refractive error. For comparison, a blur-minimization (BM) task was also performed using a monochromatic version of the stimulus. Subjects had to indicate whether the stimulus was in focus. A PlusOptix Power Refractor II was used to monitor the dynamic accommodative response during the DSR and BM tasks. Three young subjects (29±2yr) performed 10 alternating trials, with initial myopic (+1.5D) and hyperopic defocus (-1.5D, which could be accommodated). Temporal accommodative changes >0.5Hz (i.e., microfluctuations) were removed. Negative accommodative responses/speeds during repetitions represent activation, and positive represent relaxation. Mean measurement time and standard deviation (repeatability) across the 10 repetitions were compared

Results : In the BM task, hyperopic defocus was accommodated as expected but myopic defocus was not (mean response -0.65±0.26 and -0.01±0.11D, respectively, Wilcoxon test p<.05). Remarkably, the accommodative response remained stable in the DSR task (hyperopic and myopic repetitions -0.23±0.24 and -0.08±0.26D, p>.05). In the BM task, the mean speed for hyperopic and myopic defocus was -0.39±0.24 and 0.11±0.08 D/s respectively (p<.05), whereas in the DSR task the mean speed hardly changed between hyperopic and myopic repetitions (0.01±0.05 and 0±0.06 D/s, p>.05). In addition, the DSR task was on average more repeatable (±0.22D) than the BM task (±0.73D). The time per repetition was very similar (mean 12.5±5.5s for DSR and 7.2±1.6s for BM)

Conclusions : The temporal defocus wave of the DSR virtually eliminates the accommodative response during subjective refraction. This result explains the increased precision of the DSR task compared to BM, and could lead to refractive error measurements that do not require fogging or cycloplegia

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.

 

Accommodative response for S1. Upper subplots show mean defocus across the 10 repetitions (delimited by vertical dotted lines). Bottom subplots show accommodative response and speed. Gray vertical areas mean absence of stimulus. A. BM task. B. DSR task.

Accommodative response for S1. Upper subplots show mean defocus across the 10 repetitions (delimited by vertical dotted lines). Bottom subplots show accommodative response and speed. Gray vertical areas mean absence of stimulus. A. BM task. B. DSR task.

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