Abstract
Purpose :
Simultaneous image multifocal (MF) contact lens performance can be influenced by multiple patient factors including pupil size (PS), aberrations, and residual accommodation. The new kalifilcon-A multifocal daily disposable contact lens (DDCL) 3-Zone Progressive lens design accounted for accommodative amplitude, depth of focus, higher order aberrations, pupil changes as a function of object distance, corneal curvature, axial length, and residual accommodation across nine distances. The objective of the present analysis was to summarize vision and comfort performance across four PS categories.
Methods :
Habitual wearers of MF DDCL aged ≥40 years were enrolled in a 3-week, single-arm, bilateral, open-label study to assess near, intermediate, and distant vision performance. PS measurements and binocular logMAR visual acuity (VA) were recorded at the dispensing visit. At the 1-week and 3-week follow-up visits, VA was obtained, along with subjects’ lens performance ratings of vision and overall comfort using a 0-100 scale (100=most favorable).
Data obtained on individual eyes was averaged across OD and OS for a subject-wise value. Four categories spanning the range of PS were defined (Category 1: ≤ 3mm; Category 2: >3mm - 4mm; Category 3: >4mm - 5mm; Category 4: >5mm), and data were summarized within each.
For parameters at each visit, comparisons across the PS categories were performed using the Kruskal-Wallis (KW) method, testing the hypothesis that the values obtained for each category came from the same distribution. Significance is declared if the KW p-value was <0.05.
Results :
293 subjects completed the study; 69 were included in PS category 1; 128 in category 2; 75 in category 3; and 20 in category 4. Table 1 presents the median score at each visit for each category.
In no instance did the KW test indicate statistical significance among PS categories. For every parameter at every visit, the median lens performance ratings were high for all four categories.
Conclusions :
There was no indication that the distribution of VA or lens performance ratings related to vision or overall comfort differed among pupil size categories. The vision and comfort outcomes support that kalifilcon-A MF DDCL wearing experience is favorable and consistent across various pupil sizes.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.