Abstract
Purpose :
To evaluate the diagnostic accuracy and applicability of four glaucoma risk score models, developed by Fukai et al. (2022), when applied to swept source optical coherence tomography (SS-OCT) scans of both healthy and diseased eyes. Comparative analysis was also conducted using SS-OCT scans and spectral domain optical coherence tomography (SD-OCT) scans acquired on the same eyes.
Methods :
A cross-sectional study was conducted on 25 glaucoma and 25 healthy patients. Patients underwent an ocular examination to determine if they belonged in the healthy or glaucoma group. Each patient was scanned by the SS-OCT (Triton, Topcon Healthcare, Tokyo, Japan) and SD-OCT (Maestro, Topcon Healthcare, Tokyo, Japan) devices with the same eye using 12mm by 9mm widefield OCT scans. Scans were excluded from the dataset for the following reasons: blinks, motion artifacts, a TopQ score less than 25, segmentation errors, or a mispositioned optic disc. All scans from both devices were used to generate risk scores using all four models.
The performance of the models on the SS-OCT scans was compared against that on the SD-OCT scans through area under the receiver operating characteristic curves (AUROCs), sensitivity, and specificity metrics. The risk scores from both devices were independently compared within the healthy and glaucoma groups.
Results :
The risk scores derived from SS-OCT scans aligned with the risk scores obtained from SD-OCT scans in both healthy and glaucoma groups (Figure 1). The devices demonstrated comparable performance, as indicated by their AUROC values ranging from 0.95 to 0.96 (Figure 2). Among the models, model 1 showed the most significant change in sensitivity between devices, with a difference of 0.12 at 95% specificity.
Conclusions :
The performance of these models on the SS-OCT device closely resembled their performance on the SD-OCT device based on their AUROC values. The glaucoma risk score models, while originally developed using SD-OCT data, can be applied to SS-OCT scans to exhibit high performance distinguishing between healthy and glaucomatous eyes. This study indicates a promising potential for implementing the glaucoma risk score models on SS-OCT scans.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.