Abstract
Purpose :
To investigate the spatial association between CMvD and RNFL defect on ROTA in eyes with early glaucoma (i.e., VF MD > -6 dB).
Methods :
100 eyes of 91 glaucoma patients underwent visual field (VF), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) examination. CMvD was defined as complete loss of microvasculature identified in the choroidal layer on 3x3mm OCTA images. RNFL defect was evaluated on 12x9mm widefield images based on the loss in optical texture signatures along the trajectories of the axonal fiber bundles. CMvDs and RNFL defects were analyzed on a single image by overlapping the OCTA and the ROTA images. The spatial locations of CMvDs and RNFL defects were analyzed in 6 sectors with reference to the BMO centre and the fovea-BMO axis.
Results :
93 eyes showed RNFL defects on ROTA and 76 eyes had CMvDs among which 56 eyes had alignment of RNFL defects and CMvDs at the same sector. The proportion of eyes with RNFL defects (93%) was significantly higher than the proportion of eyes with CMvDs (76%) (P<0.001). Using multilevel logistic regression, the presence of CMvDs showed significant association with the presence of RNFL defects (OR=1.81; 95%CI, 1.19-2.73; p<0.05). Logistic regression analysis on individual sector revealed that the presence of CMvDs was associated with the presence of RNFL defects at the temporal (OR: 3.63; 95%CI, 1.43-9.19; P<0.05) and superotemporal quadrants (OR: 2.56; 95%CI, 1.03-6.32; P<0.05); no association was found at the other sectors.
Conclusions :
CMvD showed a spatial association with RNFL defect at the temporal and superotemporal sectors of the optic disc.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.