Abstract
Purpose :
To characterize human crystalline lens three-dimensional dimensions in vivo and identify associations among these parameters, ocular biometry, and age.
Methods :
In this study, lens thickness (LT), lens equatorial diameter (LED), lens volume (LV), lens density (LD), radius of curvature of the best fitting sphere of anterior lens surface (RAL) and radius of curvature of the best fitting sphere of posterior lens surface (RPL) were measured intraoperatively using 3-dimensional confocal structured illumination technology(3D-CSI) to image the intraocular structures from different positions in 265 eyes undergoing lens surgery. 265 patients were divided into 4 groups according to age, Group 1= Age less than 60; group 2= age greater than 60; group 70; group 3= age greater than 70; group 80; group 4= age greater than 80. Correlations among lens morphological parameters and age were analyzed.
Results :
Wide variations were observed in LT (3.91-5.97mm), LED (8.10-12.51 mm), RAL (6.87-16.17mm), RPL (4.07-6.84mm)and LV (117.17-307.30 mm3) of aging eyes. The correlation coefficients r between age and LT, RAL, RPL, LED, LV and LED are 0.390, -0.322, 0.138, 0.233, 0.412, 0.421, 0.386, 0.476, respectively. There were statistical differences in these parameters among the four groups.
Conclusions :
In this study, LT, RPL, LV, LD both increases with age, but RAL decreases with age. 3D lens modeling was used to evaluate the changes of lens shape with age, and further explore the influence of lens shape on IOL calculation, hoping to improve the accuracy of IOL selection.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.