Investigative Ophthalmology & Visual Science Cover Image for Volume 65, Issue 7
June 2024
Volume 65, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2024
The relationship between hemodynamics and structure is most strongly correlated in the temporal regions of the optic nerve in patients with primary open angle glaucoma
Lukas Ritzer; Alon Harris; Louis R. Pasquale; Brent A Siesky; Alice Chandra Verticchio Vercellin; Brendan Fry; George Eckert; Tak Yee Tania Tai; Anna Fabczak-Kubicka; Denise Alabi; Isaac Tessone; Michael Chang; Julia Arciero
Author Affiliations & Notes
  • Lukas Ritzer
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alon Harris
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Louis R. Pasquale
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brent A Siesky
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alice Chandra Verticchio Vercellin
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brendan Fry
    Department of Mathematics and Statistics, Metropolitan State University of Denver, Denver, Colorado, United States
  • George Eckert
    Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tak Yee Tania Tai
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Anna Fabczak-Kubicka
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Denise Alabi
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Isaac Tessone
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Michael Chang
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Julia Arciero
    Department of Mathematical Sciences, IUPUI School of Science, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Lukas Ritzer None; Alon Harris AdOM, Qlaris, Cipla , Code C (Consultant/Contractor), AdOM, Oxymap, Qlaris, SlitLED , Code I (Personal Financial Interest), AdOM, Qlaris, Code S (non-remunerative); Louis Pasquale TwentyTwenty, Character BioSciences, Code C (Consultant/Contractor); Brent Siesky None; Alice Chandra Verticchio Vercellin None; Brendan Fry None; George Eckert None; Tak Tai None; Anna Fabczak-Kubicka None; Denise Alabi None; Isaac Tessone None; Michael Chang None; Julia Arciero None
  • Footnotes
    Support  This work has been partially supported by NIH grants (R01EY030851 and R01EY034718), NYEE Foundation grants, Departmental Challenge Grant award from Research to Prevent Blindness, NY, NSF DMS-1654019, NSF DMS-2150108, NIH (R01EY032599), The Glaucoma Foundation.
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 1232. doi:
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      Lukas Ritzer, Alon Harris, Louis R. Pasquale, Brent A Siesky, Alice Chandra Verticchio Vercellin, Brendan Fry, George Eckert, Tak Yee Tania Tai, Anna Fabczak-Kubicka, Denise Alabi, Isaac Tessone, Michael Chang, Julia Arciero; The relationship between hemodynamics and structure is most strongly correlated in the temporal regions of the optic nerve in patients with primary open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2024;65(7):1232.

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Abstract

Purpose : To investigate the relationship between radial peripapillary capillary (RPC) vessel density (VD) and retinal nerve fiber layer (RNFL) thickness in quadrants and sectorial regions of patients with primary open angle glaucoma (POAG) and healthy controls.

Methods : In a cross-sectional analysis, 191 individuals (80 POAG; 111 healthy controls) were assessed for RPC VD and RNFL thickness at each quadrant [superior (S), inferior (I), nasal (N) and temporal (T)] and sectorial level [inferior-temporal (IT), temporo-inferior (TI), temporo-superior (TS), superior-temporal (ST), inferior-nasal (IN), naso-inferior (NI), naso-superior (NS), and superior-nasal (SN) sectors] via optical coherence tomography angiography (OCTA, Optovue). Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : Significantly higher positive correlations were found between RPC VD and RNFL thickness in the S, I, and T quadrants of POAG patients compared to healthy controls (all p<0.05). The temporal quadrant in POAG patients displayed the largest difference in correlation compared to healthy controls (Figure 1). A stronger positive correlation was also found between RPC VD and RNFL thickness in the temporal (IT, TI, TS, ST) sectors in POAG patients compared to healthy controls (all p<0.05). The TS sector of the optic nerve showed the largest difference between POAG patients and healthy controls (Figure 2).

Conclusions : POAG patients have a stronger relationship between RPC VD and structural parameters in the temporal regions of the optic nerve compared to healthy controls. The TS sector demonstrated the largest difference between groups.

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.

 

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve quadrants in primary open angle glaucoma (POAG) patients and healthy controls.
View OriginalDownload Slide

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve quadrants in primary open angle glaucoma (POAG) patients and healthy controls.

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve quadrants in primary open angle glaucoma (POAG) patients and healthy controls.

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve quadrants in primary open angle glaucoma (POAG) patients and healthy controls.
View OriginalDownload Slide
 
Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve sectors in primary open angle glaucoma (POAG) patients and healthy controls.
View OriginalDownload Slide

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve sectors in primary open angle glaucoma (POAG) patients and healthy controls.

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve sectors in primary open angle glaucoma (POAG) patients and healthy controls.

Correlation coefficients (r) and relative differences between hemodynamic (radial peripapillary capillary vessel density) and structural (retinal nerve fiber layer thickness) parameters in the optic nerve sectors in primary open angle glaucoma (POAG) patients and healthy controls.
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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