Abstract
Purpose :
Although visual field (VF) testing is a useful functional assessment for X-Linked Retinitis Pigmentosa with RPGR mutations cases, the correlation against age in the cross-sectional dataset shows loose correlation. The purpose of this study was to test the hypothesis that VFMA measurements would show tighter correlation compared to conventional VF measurements.
Methods :
A cohort with X-linked retinitis pigmentosa with RPGR mutations, processed at Casey Reading Center over five years was enrolled. VFs (Octopus 900, White/White 185 points GATE V grid at 90 degrees, Haag Streit, Koeniz, Switzerland) from 162 eyes of 162 patients were examined. Mean sensitivity (MS), volumetric hill of vision (HOV) and age were extracted from data. HOV values were collected at three different sizes of the field (90, 30, and 10 degrees). In addition, data from six eyes of three patients with four visits (baseline, 12, 18, and 24 months) were assessed to see the individual longitudinal changes using HOV.
Results :
MS and 90 degrees HOV values showed a negative correlation with age (both p<0.001-Wilcoxon test, Figure 1). Longitudinal changes of HOV values are shown in Figure 2. These volumetric values showed tighter fit compared to MS (r-square 0.38 vs 0.27). The largest dynamic range in retinal sensitivity (RS) changes was shown by 90 degrees HOV, followed by 30 and 10 degrees.
Conclusions :
Results confirmed the study hypothesis. VFMA measurements showed tighter fit for age correlation compared to conventional VF measurements. Longitudinal individual samples also showed that VFMA measurements provided quantitative disease status changes. VFMA may provide better assessment for RPGR-related X-Linked Retinitis Pigmentosa.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.