Abstract
Purpose :
To assess the interobserver reliability of quantitative anterior segment optical coherence tomography (AS-OCT) in the measurement of anterior segment angles in Hispanic/Latinos of diverse backgrounds
Methods :
Wide-angle-to-angle (WAA) and anterior chamber AS-OCT images from a convenience sample of 300 participants selected consecutively in a structured approach from the Study of Latinos “SOL” Ojos cohort, an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), were included in analysis. Images were captured using CIRRUS HD-OCT 6000 (Carl Zeiss Meditec, Inc.; Dublin, CA) equipment under dim lighting without dilation; parameters measured by each grader with Zeiss software included AOD 500, AOD 750, TISA 500, TISA 750, SSA, CCT, ATA, LV, and ACD for temporal and nasal angles in right and left eyes. Graded AS-OCT images from n=100 SOL Ojos participants from three graders (e.g., AS-OCT images from n=300 total SOL Ojos participants) were re-graded by a lead grader, and inter-agreement assessed. Intraclass correlation coefficients (ICC) were utilized to assess the inter-agreement between the lead and each of the three graders. Stratified analysis was conducted separately, by eye and angle, for narrow and wide angles to assess inter-agreement variations under different angle conditions, including phakia and pseudophakia. Statistical analysis was performed by SAS (9.4, SAS Institute, Cary, NC) and R-studio (version 2023.03.1)
Results :
Images were gradable in n=289 participants, yielding n=1156 AS-OCT gradable scans. High agreement was observed among graders as shown in Figure 1, especially in phakic eyes with open angles (ICC ranged from 0.54 to 0.93). For anterior segment measurements (AOD500, AOD750, TISA500, TISA750, SSA) among phakic eyes, ICC inter-grader agreement ranged from 0.42 to 0.88. Some differences between temporal and nasal angles were evident, with the highest agreement generally in temporal angles of phakic eyes
Conclusions :
Analyses demonstrated excellent interobserver agreement in quantitative analysis of AS-OCT measurements in diverse Hispanic/Latino participants. Analyses support standardized AS-OCT protocols in the identification of angle-closure and angle-closure glaucoma in assessment of SOL Ojos participants at the baseline visit
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.