Abstract
Purpose :
To assess the association between OCT-Angiography (OCTA) metrics and glaucoma severity in subjects imaged by a Spectral-domain (SD) robotic OCT and a swept-source (SS) OCT.
Methods :
Thirty-four eyes of twenty-six glaucoma subjects were imaged by an investigational OCTA acquisition software by both a robotic SD-OCT (Maestro2, Topcon Healthcare, Tokyo, Japan) and a SS-OCT (Triton, Topcon Healthcare, Tokyo, Japan). Custom OCTA-derived metrics were computed for the superficial vascular plexus (SVP) and analyzed against glaucoma visual field mean defect (VF MD). Linear mixed effect models analyzed the association between radial peripapillary capillary (RPC) density after large-vessel removal (Fig.1), glaucoma severity, scan quality score (device’s native, Q-mean), age, and layer thickness.
Results :
RPC density showed a significant association with glaucoma severity for both the robotic SD-OCT (2.067 dB/%, p=0.001655; Table) and SS-OCT (1.94 dB/%, p=0.004026; Table) imaging device; both associations were independent of layer thickness. Strength of the correlation (Fig. 2) was higher for the SS-OCT (R2=0.54) than the SD-OCT (R2=0.45).
Conclusions :
To our knowledge, this is the first report of OCTA metrics by the Topcon Maestro2. Investigational OCTA metrics by Maestro2 (robotic SD-OCT) performed comparably with the Triton’s (SS-OCT) OCTA metrics in their association with glaucoma severity. The highly automated capabilities of the Maestro2’s OCTA may make it a valuable tool for primary eye care and population screening programs.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.