Abstract
Purpose :
Endophthalmitis is often managed using a tap and inject method or pars plana vitrectomy (PPV). This retrospective study compared visual acuity outcomes and rates of retreatment between patients with endophthalmitis receiving tap and inject or PPV as a first intervention.
Methods :
The data were collected from a single vitreoretinal surgeon in Toronto from March 2011 to March 2023. A linear regression model was created to assess the differences in visual acuity after treatment with initial PPV versus tap and inject. A multivariable model was also designed, adjusting for age and sex. In addition, univariable and multivariable logistic regression models were made to determine the association between each treatment method and need for retreatment. Statistical analyses were carried out in Microsoft Excel.
Results :
After excluding patients with no follow up, 50 individuals were included. Tap and inject had a 6.4% higher rate of vision improvement compared to PPV. However, on multivariable logistic regression, there was no significant difference in visual improvement between treatments, adjusting for age and sex (p=0.16). Furthermore, it was found that secondary treatment was required for 5% more patients after tap and inject compared to PPV (p=0.78, 38% and 33%, respectively), which was not statistically significant on multivariable analysis (p=0.25).
Conclusions :
When adjusted for age and sex, there were no differences in visual improvement or retreatment rates between tap and inject and PPV. A large-scale clinical trial would be helpful in further exploring the association between treatment type and functional outcomes.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.