Abstract
Purpose :
To determine the proportion of eyes with OCT features of polypoidal choroidal vasculopathy (PCV) among patients diagnosed as treatment-naïve neovascular age-related macular degeneration (nvAMD) based on the Asia Pacific Ocular Imaging Society PCV Workgroup criteria
Methods :
Single-center cross-sectional chart review. Medical records of treatment-naïve nvAMD patients diagnosed between January 2018 and June 2023 were reviewed. Clinical and demographic profile at presentation were collected. Inclusion criteria were availability of spectral domain OCT images prior to treatment initiation. Exclusion criteria were diagnosis of other macular pathologies, media opacity precluding proper OCT assessment, incomplete data or imaging scans, and previous anti-VEGF, laser or retinal surgery. OCT images were evaluated by two masked graders for presence of certain OCT characteristics. A diagnosis of PCV was made based on the presence of at least 2 major OCT diagnostic criteria as defined by the APOIS PCV Workgroup Criteria. A comparative analysis between PCV and non-PCV subgroups was conducted.
Results :
Medical records of 244 patients diagnosed with nAMD were retrieved. Of these, 45 eyes of 38 patients were included in the study and analyzed. Mean age was 69.4 years old (range 53-83), 71.1% of patients were female, and 81.6% had unilateral disease. Median BCVA was 0.86 for all patients. None of the clinical and demographic characteristics were significantly different between PCV and non-PCV subgroups. Twenty-four eyes (53.3%) had at least 2 major APOIS criteria for PCV. Among PCV eyes, sub-RPE ring-like lesion was the most common major OCT criteria (87.5%), while double layer sign was the most common minor OCT criteria (100%). Major criteria sharp-peaked PED (p<0.001), sub-RPE ring-like lesion (p<0.001), en face OCT complex RPE elevation (p=0.005) and minor criteria double-layer sign criteria (p=0.007) were significantly more frequent in the PCV subgroup.
Conclusions :
More than half of Filipino eyes diagnosed with nvAMD fulfill the OCT criteria for PCV which is consistent with reported disease prevalence among other Asian populations. The APOIS PCV Workgroup Criteria is a helpful tool in screening for PCV in resource-limited settings and may help determine value of additional diagnostic and treatment options. Validation studies using indocyanine green dye are suggested.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.