Abstract
Purpose :
To describe clinical and, histological features of pigmented ocular surface squamous neoplasia (P-OSSN) in a Referral Center in Mexico City.
Methods :
Study design: Retrospective cohort. Records of Cornea and refractive surgery department from 2017 to 2023 were reviewed. The search included corneal and/or conjunctival specimens containing the terms "pigmented ocular surface squamous neoplasia" and " pigmented squamous cell carcinoma” in the diagnosis. A total of 43 cases were identified. Only biopsy-proven cases were included. Pathology reports and corresponding clinical records were reviewed for patient age and gender, involved eye, location of the lesion, self- reported progression time, histopathological diagnosis, treatment, resolution, and recurrence.
Results :
Forty three specimens were identified. Mean age of patients was 63.4 years old (+/-11.7), there were 23 (53.4%) males and 20 (46.5%) females. Right eye was affected in 25 cases (58.1%). Of 43 specimens included 15 (34.8%) were associated with a papilloma, 16 (37.2%) were reported with intraepithelial neoplasia of the conjunctiva (NIC) grade 1 and grade 2, 7 (16.2%) with NIC 3 and 4 (9.3%) as carcinoma in situ. Recurrence occurred in 4 patients (9.3%).
Conclusions :
Pigmented ocular surface squamous neoplasia are frequent. Treatment with 5-Fluoracil is effective in the management of p-OSSN, with a complete resolution of the tumor and only 4 recurrences in our study.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.