Abstract
Purpose :
To investigate the myopia control efficacy of spectacle lenses with positive power lenslets and spectacle lenses with negative power lenslets in a 1-year clinical trial.
Methods :
Two hundred and forty Chinese myopic children (aged 6 to 12 years old, myopia between -1.00D and -4.00D) were randomly assigned to three groups: LARI lenses with positive power lenslets (PLARI), LARI lenses with negative power lenslets (NLARI), or single-vision lenses (SVL) for 1 years. Spherical equivalent of cycloplegic autorefraction (SER) and axial length (AL) were measured every six months.
Results :
A total of 231 children completed the 1-year study, with 76 in PLARI, 77 in NLARI and 78 in SVL group, respectively. At 1 year, the SER changes in the PLARI (-0.30±0.48D) and NLARI (-0.21±0.35D) groups were smaller than those in SVL group (-0.66±0.40D, both P<0.001), representing 55% reduction for PLARI and 68% reduction for NLARI. The AL elongation was slower in the PLARI (0.19±0.20mm) and NLARI (0.17±0.14mm) groups than in the SVL group (0.34±0.18mm, both P<0.001), representing 44% reduction for PLARI and 50% reduction for NLARI. There was no significant difference in SER changes and axial elongation between PLARI and NLARI groups (P=0.542 and P=1.00, respectively). A younger age was associated with more rapid SER increase and greater axial elongation in the SVL (r=0.429, P<0.001 and r=-0.623, P<0.001, respectively) and PLARI (r=0.444, P<0.001 and r=-0.511, P<0.001, respectively) groups, but not in the NLARI group (r=0.023, P=0.843 and r=-0.097, P=0.40, respectively). In children aged 6-8 years, the SER increase (-0.22 ± 0.34D) and axial elongation (0.19 ± 0.14mm) in NLARI group were lower than those in PLARI group (-0.67 ± 0.52D, P=0.003; 0.35 ± 0.22mm, P=0.015). In children aged 9-10 years and 11-12 years, there was no significant difference in SER increase and axial elongation between NLARI group and PLARI group.
Conclusions :
Both spectacle lenses with positive power lenslets and spectacle lenses with negative power lenslets could significantly slow myopia progression and axial elongation in children over a 1-year period, compared with SVL. NLARI had similar myopia control effect on children of different ages, and was better than PLARI on younger children (aged 6-8 years).
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.