Abstract
Presentation Description :
Effective treatment for reversing sight-loss caused by photoreceptor degeneration remains a major goal for current research. Here, I will discuss recent progress in the development of stem cell-derived photoreceptor replacement therapy, with a particular emphasis on cell suspension-based approaches and the treatment of advanced retinal disease. We have previously reported the restoration of retinal and visual function following the transplantation of human stem cell-derived cone photoreceptors, and are now examining the potential breadth of application, together with some of the challenges and promising prospects for re-establishing functional synaptic connectivity and donor cell polarisation in the aged and advanced disease environment.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.