Abstract
Purpose :
To create a computational fluid dynamics (CFD) model of ocular anterior segment for primary angle closure diseases (PACD) and assess the aqueous humor (AH) dynamics in different angle closure ranges (ACRs).
Methods :
mography image by SOLIDWORKS. Three different angle opening distance at 750 µm from the scleral spur (AOD750) values of 0.05mm, 0.15mm and 0.40mm were established according to previous literature data, which represent the structures of primary angle closure glaucoma (PACG), primary angle closure (PAC), and PAC suspect (PACS). The AH dynamics were modelled using the Navier-Stokes equation, combined with realistic anterior segment boundary conditions. A 3D CFD model of the ocular anterior segment was created in COMSOL Multiphysics. The major outcome was the maximum flow velocity (MFV) at the anterior chamber angle (ACA).
Results :
The MFV showed a non-linear association with ACR in the numerical models of PACD. The MFV started to elevate when ACR larger than 180°, and increased obviously when the ACR larger than 270°. The MFV at the ACA was highest in the PACG and lowest in the PACS.
Conclusions :
The association between the ACR and MFV is an ascending curve in PACD, and ACR of 180° and 270° are two critical turning points. Our results may provide a better guidance for the clinical management of PACD in different stages.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.