Abstract
Purpose :
To investigate longitudinal changes in choroidal vascularity index (CVI) in uveitis patients at baseline with active inflammation and at 6 months.
Methods :
This case and control study included 49 patients with anterior, intermediate, posterior or pan-uveitis and 49 healthy controls. One eye per patient was included. Uveitis patients were recruited at baseline with active inflammation. Clinical data and multimodal imaging including optical coherence tomography (OCT) were obtained at baseline and 6 months. Both 2-dimensional (2D) subfoveal CVI and 3-dimensional (3D) macular CVI were measured using previously published algorithm. Comparison between uveitis and control group as well as between baseline visit and 6 months visit in the uveitis group were performed using ANCOVA model.
Results :
Mean age in uveitis and control group was 50.6±12.8 and 50.2±13.4 years, respectively (p=0.878). At baseline, the mean 2D CVI was significantly lower in uveitis group (62.4% vs 63.8%, p=0.007) and the mean 3D CVI also showed a lower trend in uveitis group (62.0% vs 62.8%, p=0.109). In uveitis group, both 2D and 3D CVI were higher at 6 months compared to baseline but both were not statistically significant (p=0.055 and 0.177, respectively). Uveitis patients who were still clinically active at 6 months had significantly lower 2D and 3D CVI at baseline compared to those who were clinically quiescent at 6 months (p=0.027 and 0.008, respectively).
Conclusions :
Changes in CVI is correlated with the diagnosis and prognosis of uveitis patients. CVI may be a useful outcome measure in the uveitis management and clinical trials.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.