Abstract
Purpose :
To investigate the influence of tyrosinase in the development of myopia on guinea pigs
Methods :
A total of 80 guinea pigs were examined, comprising 48 pigmented hyperopic and 32 albino myopic individuals. Guinea pigs were randomly assigned to five groups: PLK, PL, AL, PH, and AM. A 3D-printed headgear was used for lens-induced myopia in the PLK, PL, and AL groups, with the right eye wearing a -10D lens. The PLK group received kojic acid. Refractive error, axial length (AL), corneal curvature radius (CCR), corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), anterior chamber angle depth, choroidal thickness (ChT), and choroidal blood perfusion (ChBP) were measured at weeks 3, 5, and 7.
Results :
There was a noticeable difference in the reduced refractive error, with the PLK group higher than the PL group. Except for the PH and AM groups, there were differences in refractive error between the left and right eyes of all guinea pigs. The decrease in choroidal thickness (ChT) in the AL group was higher than in the AM group. The reduction in ChT and choroidal blood perfusion (ChBP) in the PLK group exceeded that in the PL and PH groups. The decrease in refractive error in the PLK group was significantly higher than in the PL group.
Conclusions :
Based on the comprehensive findings, our study reveals a significant impact of tyrosinase inhibitors on the development of myopia. Furthermore, changes in choroidal structure and blood perfusion suggest potential mechanisms of tyrosinase in ocular physiological processes. These research results provide essential clues for further exploring the mechanisms of myopia regulation and lay the foundation for the development of future therapeutic strategies.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.