Abstract
Purpose :
To evaluate the changes in ocular refractive development, choroidal thickness (ChT), and choroidal blood flow (CBF) in guinea pigs with form-deprivation myopia (FDM) treated with repeated low-level red-light (RLRL) therapy.
Methods :
Twenty-eight 3-week-old male tricolor guinea pigs were randomly divided into the normal control (NC) group (n = 10), the form deprivation (FD) group (n = 10), and the red-light (RL) group (n = 8). Noninvasive optical coherence tomography angiography was utilized to detect the ChT, vascular area density (VAD), vascular skeleton density (VSD), and blood flow signal intensity (Flux) in FDM guinea pigs treated with RLRL therapy.
Results :
The NC group had a higher ChT than the FD group at week 1 (P<0.05). At weeks 2 and 3, the NC group had a higher ChT than the FD and RL groups, and the RL group had a higher ChT than the FD group (all P<0.05). Additionally, the NC group had a higher VAD, VSD, and Flux of the choriocapillaris layer than the FD group at three follow-up time points (all P<0.05). The Flux in the NC group was also higher than that in the RL group (all P<0.05). At week 3, the NC group had a higher VSD than the RL group, and the VSD and Flux were higher in the RL group than in the FD group (all P<0.05). Correlation analysis results showed that weekly changes in refraction were positively correlated with changes in axial length and ChT (all P<0.05). AL and ChT changes were positively correlated (P＜0.05). ChT changes were positively correlated with changes in the VAD, VSD, and Flux in the choriocapillaris layer, as well as VSD and Flux changes in the medium and large vessel layers (all P<0.05).
Conclusions :
RLRL therapy can effectively inhibit the progression of FDM in guinea pigs, which may be related to an increase in CBF in the choriocapillaris layer. This study provides animal model evidence for the effective inhibition of myopia progression by RLRL.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.