Abstract
Purpose :
To find the prevalence of biofilm producing bacteria in bacterial keratitis (BK) patients and to compare the resistance pattern and clinical outcome of biofilm producing (BP) and non-biofilm producing bacteria (NBP).
Methods :
Bacterial isolates obtained from corneal scrapings were analysed for biofilm
formation with XTT and crystal violet assay in an invitro study. Antimicrobial susceptibility pattern of isolates and clinical outcome were compared.
Results :
Of 103 bacterial isolates 75 were found to strong biofilm producer. Resistance pattern of BP and NBP bacteria was found to be; Moxifloxacin (40% in BP vs 33.33% in NBP, p=0.06), Gatifloxacin (41.53% in BP vs 36.36%in NBP, p= 0.06), Ciprofloxacin (35.35% in BP vs 54.54 % in NBP, p=0.39) and Ofloxacin(40 % in BP vs 42.85 % in NBP, p=0.10 ). Out of 75 biofilm producers, 27 (36%) cases had undergone additional surgical procedures.
Conclusions :
There is no significant difference in resistance pattern and clinical outcome.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.