Abstract
Purpose :
To prospectively compare measurements of higher-order aberrations (HOAs) between wavefront-guided and topography-guided laser in situ keratomileusis (LASIK) surgery in the treatment of myopia with and without astigmatism.
Methods :
This prospective, randomized, fellow eye-controlled clinical trial involved 100 eyes of 50 patients with myopia or compound myopic astigmatism who underwent wavefront-guided (WFG) LASIK in 1 eye and topography-guided (TG) LASIK in the fellow eye. Eyes were randomized according to ocular dominance. Wavefront aberrometry was performed pre-operatively and post-operatively and eyes were evaluated for the root mean square (RMS) of the HOAs, coma, trefoil, and spherical aberration.
Results :
Pre-operatively, the mean RMS of HOAs was 0.36 ± 0.13 in the WFG group and 0.35 ± 0.12 in the TG group (p = 0.78), mean coma was 0.20 ± 0.10 in the WFG group and 0.17 ± 0.09 in the TG group (p = 0.30), mean trefoil was 0.17 ± 0.09 in the WFG group and 0.18 ± 0.09 in the TG group (p = 0.70), and mean spherical aberration was 0.09 ± 0.14 and 0.09 in the WFG group ± 0.14 in the TG group (p = 0.87).
At post-operative month 1, there were no significant differences between the WFG group and TG group in post-operative month 1, with the mean RMS of HOAs (p = 0.31), mean coma (p = 0.19), mean trefoil (p = 0.18), and mean spherical aberration p = 0.53).
At post-operative month 3, there were no significant differences between the WFG group and TG group in the mean RMS of HOAs (p = 0.92), mean coma (p = 0.74), mean trefoil (p = 0.62), and mean spherical aberration p = 0.77).
At post-operative month 6, there were no significant differences between the WFG group and TG group in the mean RMS of HOAs (p = 0.09), mean coma (p = 0.06), mean trefoil (p = 0.57), and mean spherical aberration p = 0.68).
Conclusions :
Wavefront-guided LASIK and topography-guided LASIK achieve similar results with regards to measure of higher-order aberrations at 1-, 3-, and 6-months post-operation.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.