Abstract
Presentation Description :
The presentation will apply the concepts of mechanobiology and pressure sensing to steady-state signaling in retinal ganglion cells (RGCs) and glia, with a focus on mechanosensitive ion channels and calcium homeostasis. Neurons and glia were found to be highly sensitive to pressure, strain and swelling. Pharmacological stimulation of mechanotransducers altered neuronal excitability and glial activation while inhibition and gene ablation had protective effects in animal models of glaucoma.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.