Abstract
Purpose :
To explore the characteristics of retinal peripheral refraction in myopic children administering 0.05% atropine eyedrop at different frequencies.
Methods :
116 myopic children completed this 1-year prospective study and were randomly assigned to Once daily, Twice per week, or Once per week groups. Peripheral refraction (PR, and relative, RPR) from a visual field of horizontal 60° and vertical 36° was measured with a custom-made Hartmann-Shack wavefront peripheral sensor. Spherical equivalent (SE) and axial length (AL) were also measured.
Results :
After 1-year atropine administration, SE and AL increased by 0.14 D and 0.10 mm (Once daily), 0.24 D and 0.17 mm (Twice per week), 0.58 D and 0.28 mm (Once per week), respectively. Among groups, Once per week showed more myopic PR from retina’s nasal 10.5° to temporal 10.5°, and superior 5.5° to inferior 5.5°; Once daily and Twice per week showed more myopic RPR outward retina’s superior 5.5°, nasal 10.5°, and temporal 10.5°.(p < 0.05) Individually, Once daily group’s RPR showed myopic shift in retina’s all regions and that of Twice per week group in retina’s temporal and inferior (p < 0.05), while no change in Once per week group (p > 0.05). Besides, RPR’s myopic shift in retina’s temporal was significantly associated with less myopic progression, notably in the once-daily group. (p < 0.05)
Conclusions :
0.05% atropine eyedrop increased myopic RPR and slowed central myopia progression with frequency dependence, as the effect was strongest with once-daily. Myopia control through atropine might alter the elongated retinal shape more oblate.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.