Abstract
Purpose :
It is imperative to mitigate the onset of high myopia by minimizing the progression of myopia during early childhood. Orthokeratology (OK) is a clinical technique that uses specially designed rigid contact lenses to reshape the cornea to temporarily reduce or eliminate refractive error. However, it has been observed that young children may exhibit poor response to OK, as they continue to experience rapid progression of myopia despite its use. We performed a retrospective study to compare the effectiveness of the combined treatment of low-dose atropine and OK in controlling myopia in children with a poor response to OK.
Methods :
91 children who experienced two years of OK treatment were analyzed in this retrospective study. They were aged between 6-12 years old. when they started OK treatment. All children showed an annual increase of 0.3mm or greater in the first year of treatment of OK. The children with combination treatment with 0.01% atropine in the second year were defined as the OKA 0.01% group, and combination treatment with 0.05% atropine was defined as the OKA 0.05% group. The monotherapy of the OK (monoOK) group included children without any combined atropine therapy in the second year. This study analyzed the change in AL in the second years. The difference in the AL of the second year among the three groups was also analyzed.
Results :
Results: There was no significant difference between the OKA 0.01% group and the monoOK group in the second year (P=0.735) in AL. However, OKA 0.05% showed shorter AL than the OKA 0.01% group (P=0.035) and the monoOK group (P=0.001) in the second year. The AL change of the second year in the OKA 0.05% group was smaller than the OKA 0.01% group (P=0.031) and monoOK group (P<0.001), and there was no significant difference between OKA 0.01 and the monoOK group (P=0.755). The AL change of the second year in the OKA 0.05% group was correlated with baseline AL (R=0.84, P<0.001), and was not correlated with age (P=0.243), gender (P=0.184) and the change of pupil diameter after atropine usage (P=0.948).
Conclusions :
For the OK poor response in young children, additive use of 0.05% atropine can control the fast progress of axial elongation elongation compared to combining 0.01% atropine.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.