Abstract
Purpose :
To evaluate the structure and function relationship in glaucoma patients using a novel imaging device that combines ultra wide-field scanning laser ophthalmoscopy (UWF-SLO) imaging with spectral domain optical coherence tomography (SD-OCT).
Methods :
Correlations between structure and function were assessed in 33 glaucoma patients with visual field loss. Humphrey Field Analyzer (HFA) 24-2 visual fields (Zeiss, Dublin, CA) were obtained on all subjects along with SD-OCT imaging on the Monaco device (Optos, Dunfermline UK), a combined UWF-SLO and SD-OCT imaging device. The average mean deviation (MD) for visual fields was -5.75 dB with a standard deviation of 4.5. The average pattern standard deviation (PSD) for visual fields was 6.23 dB with a standard deviation of 3.5. A regression analysis was performed between MD and PSD on various OCT measurements including retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, and optic nerve head (ONH) parameters. In addition, more local correlations were performed using the average superior and inferior hemiretina sensitivity values with superior and inferior RNFL quadrant thickness values.
Results :
The strongest correlations between MD and OCT measurements were for average RNFL thickness (r=0.41) and inferior quadrant RNFL thickness (r=0.42). GCC thickness and ONH parameters were generally lower and correlated with MD ranging from superior GCC thickness (r=0.003) to inferior GCC thickness and rim area (both with r=0.3). For PSD, the strongest correlations were for inferior quadrant RNFL thickness (r = 0.39) and average RNFL thickness (r = 0.28). When comparing local superior and inferior hemiretina sensitivity values with superior and inferior RNFL quadrant thickness values, the correlation improved with r = 0.49 between inferior quadrant RNFL thickness and superior hemiretina sensitivity values.
Conclusions :
Monaco OCT measurements correlate moderately well with HFA global indices including MD and PSD in a group of patients with moderate glaucoma. The strongest correlations were for average and inferior quadrant RNFL thickness values. Local correlations utilizing visual field sensitivity values improve the correlations, presumably because there are often local field defects and more local RNFL thickness loss. These results suggest the Monaco provides useful clinical information of the status of glaucoma.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.