Abstract
Purpose :
We previously reported that atopic dermatitis affects the recurrence of keratoconus after transplantation. We also examined whether corneal biomechanical properties (CBP) were decreased, but it was difficult to accurately evaluate because of the influence of individual differences. In this study, we investigated changes in CBP the 2-year period in patients who had undergone transplantation for more than 15 years, and searched for background factors that may have influenced.
Methods :
Twenty-four eyes of 20 keratoconus patients who visited the Juntendo University between January 2021 and September 2023, and whose Corvis ST could be measured twice, more than 15 years after penetrating corneal transplantation, were included. First, CBP factors that changed significantly over the 2-year period were extracted (paired t-test). Next, multiple regression analysis using generalized estimating equations was performed to determine whether background factors (atopic dermatitis, rubbing, allergic conjunctivitis, and rigid gas-permeable lens (RGPCL) use) affected the changes in the extracted factors, after confirming the relationship with age and gender.
Results :
The mean age was 61.5±9.7 years, and the mean postoperative period was 21.0±9.8 years. deflection area increased with RGPCL use (coefficient 0.24), and integrated radius decreased with RGPCL use and increased with atopic dermatitis and allergic conjunctivitis (coefficients -10.7, +14.7, +14.0).
Conclusions :
The results suggest that background factors may influence CBP in post-transplantation keratoconus.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.