Abstract
Purpose :
We conducted a retrospective DVH analysis of cases with corneal complications following radiation therapy and explored potential risk factors.
Methods :
We retrospectively reviewed 25 cases diagnosed with radiation-induced corneal complications in ophthalmology after undergoing radiation therapy at our institution from May 2011 to February 2022.
Results :
The median age was 65 years (range: 30-81 years), with 10 cases of maxillary sinus cancer, 3 cases of other paranasal sinus cancers, and 12 cases of other diagnoses. The median dose was 60 Gy (range: 30.6 Gy-70 Gy), delivered through 12 cases of 3D-CRT, 4 cases of IMRT, and 9 cases of combined 3D-CRT and IMRT. Chemotherapy was used in 16 cases, molecular targeted therapy in 2 cases, and 7 cases had no concurrent treatment. The median time from the end of radiation therapy to the first ophthalmology consultation was 4 months (range: 0-83 months). Of the 50 eyes in 25 cases, corneal complications were observed in 30 eyes, with concurrent eye diseases (retinopathy, glaucoma, cataracts, etc.) identified in 22 of these eyes. The median eyeball D max was 62.9 Gy (31.23 Gy-75.33 Gy) in the corneal complication group and 39 Gy (0.52 Gy-57.84 Gy) in the non-complication group. The median eyeball D mean was 56.19 Gy (14.34 Gy-72.62 Gy) in the complication group and 21.8 Gy (0.25 Gy-49.38 Gy) in the non-complication group. Both eyeball D max > 45 Gy and eyeball D mean > 40 Gy were significantly associated with the occurrence of corneal complications in both univariate and multivariate analyses.
Conclusions :
Eyeball D max > 45 Gy and eyeball D mean > 40 Gy are considered risk factors for corneal complications following radiation therapy.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.