Abstract
Purpose :
HerpesZosterOphthalmicus (HZO)is a disease commonly affecting the elderly and immunocompromised .Over last several years, we observed a trend of decreasing age incidence albeit with varying clinical features.This temporal trend towards younger age group,necessitates a detailed evaluation to determine possible causes contributing to its occurrence in this population.
Methods :
This is a retrospective hospital-based cross-sectional study.154 datasheets were initially identified.After the exclusion of non-relevant datasheets(88), in adherence to inclusion criteria. 56 with relevant and complete records were subjected to comprehensive analysis.Data was analyzed using IBM SPSS Software™ version 24 & computed into descriptive statistics (number, percentage, mean) of tables and diagrams.Proportional bar diagram& pie charts are used for quantitative data.
Results :
Commonest affected age group was <40 yrs, mean age being 38 yrs.Conjunctivitis was of most frequent occurrence in 82.05%. Keratitis in varying forms was seen as – epithelial-64.44%, stromal-15.3% & nummular -2.56%.Anterior uveitis in 35.89%,posterior uveitis-7.69%cases, posterior segment involvement in 8.8%,secondary glaucoma in 28.2% ,Optic nerve involvement in 5.2% while orbital apex and cavernous sinus involvement was seen in one case.
Conclusions :
This study is a representative investigation, reflecting temporal shift towards younger age group. Reported outcomes can be valuable in understanding the evolving patterns of HZO, mitigating complications and improving patient care.Several factors contribute to the potential risk, recurrence and chronicity of the disease which include demographic factors, immune status, dietary factors , environmental associations, vaccination status, and previous history of recurrences .
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.