Abstract
Purpose :
To explore changes in two-dimensional peripheral refraction, higher-order aberrations (HOAs), choroidal thickness (CT) and lenses decentration induced by orthokeratology in myopia children based on propensity score matching (PSM)
Methods :
Two-dimensional peripheral refraction and HOAs in a rectangular field were obtained using an open-view Hartmann–Shack wavefront sensor, covering a horizontal range of 60° and a vertical range of 36°. The regions were labeled UZ1, UZ2, UZ3, and UZ4 and LZ1, LZ2, LZ3, andLZ4 (for superior retina or inferior retina from temporal side to nasal side, respectively).All measurements were taken at the baseline, one, three, six and twelve months after lens fitting. The subjects were divided into two groups according to the one-year axial length (AL) change. PSM was conducted to reduce confounding bias between the groups based the baseline parameters, including age, gender, number of myopic parents, visual behavior, spherical equivalent refractive(SER),flat k, steep k, eccentricity, anterior chamber depth, pupil diameter, baseline AL, peripheral refraction (PR), relative peripheral refraction (RPR), J0 astigmatism, J45 astigmatism, spherical aberration (SA), and horizontal coma (hCOMA), vertical coma (vCOMA),the root-mean square of higher order aberration (RMSHOA). Then the changes in these parameters between the two groups were compared.
Results :
In total, 98 myopic children (age = 12.34 ± 1.88 years, SER = –2.55± 1.14 D) were available for analysis. The subjects were divided into two groups, low growth group (n=33) and higher growth group (n=65). Compared with those in the higher growth group, subjects in the low growth group exhibited older age and more hyperopia PR and RPR in the UZ3, LZ3, LZ4 regions and more RMSHOA in the LZ1, LZ2 regions (all P<0.05) at baseline. With protensity score matching, 19 pairs of myopic children were successfully matched. Subjects in the low growth group had more positive SA change in the UZ3 region and more negative hCOMA change in the UZ3, LZ3, LZ4 regions at one month (all P<0.05).
Conclusions :
No significant differences were observed in mean decentration distance, PR, RPR, J0 ,J45,vCOMA, RMSHOA, and CT after lens fitting between the two groups. Children with higher baseline hyperopic PR and RPR, more positive SA changes, and more negative hCOMA changes exhibited better myopia control.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.