Investigative Ophthalmology & Visual Science Cover Image for Volume 65, Issue 7
June 2024
Volume 65, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2024
Comparison of swept-source AS-OCT versus spectral domain AS-OCT in the automated quantification of anterior chamber cells
Joseph Privratsky; Shani Pillar; Shin Kadomoto; Nicolette Zargari; Nina Cherian; Saitiel Sandoval Gonzalez; Keren Chen; Nicholas Jackson; Giulia Corradetti; SriniVas R Sadda; Gary Holland; Edmund Tsui
Author Affiliations & Notes
  • Joseph Privratsky
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Shani Pillar
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Shin Kadomoto
    Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu, Kyoto, Kyoto, Japan
  • Nicolette Zargari
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Nina Cherian
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Saitiel Sandoval Gonzalez
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Keren Chen
    Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, United States
  • Nicholas Jackson
    Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, United States
  • Giulia Corradetti
    Doheny Eye Institute, Los Angeles, California, United States
  • SriniVas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
  • Gary Holland
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Edmund Tsui
    UCLA Jules Stein Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Joseph Privratsky None; Shani Pillar None; Shin Kadomoto None; Nicolette Zargari None; Nina Cherian None; Saitiel Sandoval Gonzalez None; Keren Chen None; Nicholas Jackson None; Giulia Corradetti Nidek, Code F (Financial Support); SriniVas Sadda 4DMT, Abbvie, Alexion, Allergan Inc., Alnylam Pharmaceuticals, Amgen Inc., Apellis Pharmaceuticals, Inc., Astellas, Bayer Healthcare Pharmaceuticals, Biogen MA Inc., Boehringer Ingelheim, Carl Zeiss Meditec, Catalyst Pharmaceuticals Inc., Centervue Inc., GENENTECH, Gyroscope Therapeutics, Heidelberg Engineering, Hoffman La Roche, Ltd., Iveric Bio, Janssen Pharmaceuticals Inc., Nanoscope, Notal Vision Inc., Novartis Pharma AG, Optos Inc., Oxurion/Thrombogenics, Oyster Point Pharma, Regeneron Pharmaceuticals Inc., Samsung Bioepis, Topcon Medical Systems Inc., Code C (Consultant/Contractor), Carl Zeiss Meditec, Heidelberg Engineering, Optos Inc., Nidek, Topcon, Centervue, Code F (Financial Support), Carl Zeiss Meditec, Heidelberg Engineering, Nidek Incorporated, Novartis Pharma AG, Topcon Medical Systems Inc., Code R (Recipient); Gary Holland None; Edmund Tsui Eyepoint, Kowa, Oculis, Code C (Consultant/Contractor), Pfizer, Cylite, Code F (Financial Support)
  • Footnotes
    Support  NEI K23EY032990; Unrestricted grant from Research to Prevent Blindness, Inc.
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 3025. doi:
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      Joseph Privratsky, Shani Pillar, Shin Kadomoto, Nicolette Zargari, Nina Cherian, Saitiel Sandoval Gonzalez, Keren Chen, Nicholas Jackson, Giulia Corradetti, SriniVas R Sadda, Gary Holland, Edmund Tsui; Comparison of swept-source AS-OCT versus spectral domain AS-OCT in the automated quantification of anterior chamber cells. Invest. Ophthalmol. Vis. Sci. 2024;65(7):3025.

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Abstract

Purpose : Anterior segment optical coherence tomography (AS-OCT)-based techniques for counting anterior chamber (AC) cells correlate with Standardization of Uveitis Nomenclature (SUN) clinical grading, while offering the potential for automation, objectivity, and precision. Utilizing high-resolution swept-source AS-OCT (ANTERION®, Heidelberg Engineering, Heidelberg, Germany) may allow superior sensitivity in the visualization and quantification of hyper-reflective foci (HRF) within the AC when compared to other platforms. The aim of this study was to compare the number of detected HRF from swept-source AS-OCT images to those detected on spectral domain AS-OCT (Optovue Avanti RTVue XR, Optovue Inc., Fremont, CA, USA) images in patients with and without active uveitis.

Methods : Forty-one eyes (32 eyes with a history of anterior segment inflammation and 9 eyes of healthy controls) of 28 patients were imaged with both swept-source and spectral domain AS-OCT during the same clinical visit. Custom developed automated algorithms were used to quantify the number of HRF. The relationship between devices for HRF quantification was assessed using Spearman rank correlation.

Results : The SUN clinical grades for enrolled eyes were: Grade 0 (N= 35); 0.5+ (N= 2); 1+ (N= 4). None of the enrolled eyes had a SUN clinical grade of 2+ or higher. The median number of HRF detected at each grade with swept-source versus spectral domain AS-OCT were: Grade 0 (3 versus 0); 0.5+ (8.5 versus 0); and 1+ (21 versus 2.5). Statistical analysis did not demonstrate a significant correlation in the HRF count between the two devices with a Spearman rank correlation of 0.131 (p = 0.400).

Conclusions : The number of detected AC HRF by swept-source and spectral domain AS-OCT imaging at the same visit did not show a significant correlation with consistently more HRF detected on swept-source AS-OCT. Swept-source AS-OCT may be more sensitive at identifying HRF at low levels of inflammation. A larger sample size of patients imaged using both techniques is necessary to further elucidate the clinical relevance of identifying HRF at low levels of inflammation.

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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