Abstract
Purpose :
To investigate factors associated with the variability of longitudinal visual field (VF) test in patients with primary open-angle glaucoma (POAG).
Methods :
Patients with VFs ≥ 12 who were followed-up for ≥ 6 years were included in this retrospective study. The linear regression of 52 TDVs (total deviation values) of VF series for each eye was performed against time (years) and the root mean square error (RMSE) of the residuals was used to measure long-term VF variability. Variable clustering through hierarchical clustering was performed to select variables and Spearman’s correlation was used as a similarity index. To adjust inter-eye correlation, we fitted mixed effect linear regression model and evaluated factors associated with long-term visual field variability in each regression model.
Results :
246 eyes of 157 patients with POAG were included. Worse baseline retinal nerve fiber layer (RNFL) thickness, lower baseline intraocular pressure (IOP), lower mean IOP, and larger IOP fluctuation were associated with increased long-term VF variability in RNFL thickness model. (all P ≤ 0.036). Worse baseline VF MD, lower baseline IOP, and larger IOP fluctuation were associated with increased long-term VF variability in MD model (all P ≤ 0.025).
Conclusions :
Greater long-term VF variability was associated with lower RNFL thickness measured by OCT, worse VF MD, lower IOP at basline visit and with mean IOP and larger IOP fluctuation in patients with POAG.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.