Abstract
Purpose :
To report the rates of visual field progression based on Glaucoma Progression analysis of Humphrey Visual Field analysis
Methods :
We included eyes with at least 5 visual fields from a large cohort of patients from a tertiary care hospital. Progression was defined based on Glaucoma progression analysis using both trend and event analysis at their last visit. Eyes with “Likely progression” on Event analysis or statistically significant slope of progression on trend analysis were classified as progressing. Demographic and visual field parameters were compared between both progressing and non-progressing eyes.
Results :
We included 125935 fields of 16497 eyes( 9932 patients ). Mean age was 51.9(Sd: 15.2) years and the majority were males. There was an average of 7.6 fields per eye. Mean baseline MD was -9.7(SD:8.3), PSD was 5.46(SD: 3.85) and VFI was 77.4 (SD: 26.3). 4396 ( 26.6%) eyes of 3540 patients showed progression on GPA event analysis as defined. 4060(24.6%) eyes of 3261 patients showed progression GPA trend analysis.
The mean age of non-progressing patients at baseline was older at 53.0(SD:14.6) years compared to the progressing eyes ( 51.4 (SD: 15.5 years)) (P<0.001)) . The mean baseline VFI(75.1(SD: 28.3) vs 83.9 (SD: 18.3), baseline MD(-10.4(SD:8.9) vs -7.6(SD:6.1) and baseline PSD(5.6(SD:4) vs 5.1(SD: 3.5) values were worse in the non progressing group as compared to the progressing group (all p< 0.0001).
Conclusions :
A significant proportion of patients with glaucoma in this large dataset showed visual field progression over time. Younger age and better MD, PSD and VFI at baseline were associated with greater risk of progression.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.