24-HOUR MOVEMENT GUIDELINES AND THE INCIDENCE OF GLAUCOMA: THE SUN STUDY

Abstract

Purpose : The 24-hour Movement guidelines is a lifestyle score that incorporates physical activity, sedentary behavior, and sleep. It was developed by the Canadian Society of Exercise Physiology as a tool to assess movement behaviors throughout the entire day, and previous papers indicate that it is an estimate of mortality risk. The goal of this study is to determine the relationship between this score and glaucoma incidence in the "Seguimiento Universidad de Navarra" (SUN) cohort.

Methods : In this prospective and dynamic cohort, 14 279 participants initially free of glaucoma were included (182 732 person-year). The total follow-up period of this study was 12.88 +/- 5.36 years. Participants answered a lifestyle questionnaire biennially, resulting in 7 possible periods of follow-up. Diagnosis of glaucoma was collected biennially through self-reported questionnaires and validated in a subsample. To evaluate adherence to this score, participants were categorized according to discrete measure of 0 to 3 points. Participants earn 1 point if the sedentary lifestyle factor =/< 8 total hours sitting and =/< 3 hours a day watching TV or computer; 1 point if there is >150 minutes of moderate activity per week, or more than 75 minutes of vigorous activity per week, or a combination of both; and 1 point if sleep is between 7 and 9 hours every day. In all other cases, participants were awarded 0 points. The outcome was the incidence of self-reported glaucoma. The statistical analysis was performed using a multivariable adjusted Hazard-Ratio (HR) with a 95% Confidence Interval (CI) across four categories, using a time-dependent Cox regression analysis multivariable model (STATA 12.0).

Results : During the follow-up, 222 new cases of glaucoma were identified. Participants with a score of 3 have lower risk of glaucoma incidence than those with score 0-1 (adjusted HR: 0.66; 95% CI: 0.45-0.97). Only low sedentary lifestyle, in isolation, was associated with a lower glaucoma incidence (adjusted HR: 0.70; 95% CI: 0.53-0.93). For each point increase in the score, the risk of glaucoma incidence decreased by 17% (p: 0.031).

Conclusions : Our results suggest that the incidence of glaucoma is related with a healthy balance between physical activity, sedentary behavior, and sleep. Of the three factors, only a low sedentary lifestyle stands out as the main factor associated with a reduced risk of glaucoma incidence.

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.