Abstract
Purpose :
To evaluate potential central serous chorioretinopathy (CSC) biomarkers of activity, using fundus imaging parameters, such as meridian breaks, choroidal vascular density, vasodilation, and thickness.
Methods :
Forty-six eyes diagnosed with unilateral and active central serous chorioretinopathy (CSC) were included in this series. Choroidal thickness was measured through optical coherence tomography images, and meridian breakage and choroidal vasodilation were evaluated using video angiography with indocyanine green. The assessment of vasodilation involved a comparison with the established normal standards observed in eyes without any ocular pathology. Additionally, choroidal vascular density was quantified utilizing Image J software. The statistical analysis, representing categorical variables as numbers and proportions, and continuous variables as mean ± SD, was conducted using the SPSS 20.0 program.
Results :
Twenty-three eyes exhibiting active CSC demonstrated a notably higher prevalence of meridian breaks (83.3%) compared to their fellow eyes (50.0%) (p=0.023). Although the choroidal vasodilation was more common in eyes with active CSC (58.3%), this difference did not reach a statistical significance (p=0.344). While the choroidal vascular density tended to be higher in the affected eyes (51.9%±14.2) than in the fellow eyes (45.2%±11.1), this difference did not achieve a statistical significance (p=0.079). Eyes with active CSC had greater choroidal thickness (424.46 µm ± 103.03) in comparison with the fellow eyes (324.14 µm ± 39.25), indicating a statistically significant difference between the two groups (p=0.001).
Conclusions :
Our study findings can improve the understanding of CSC pathophysiology since the meridian breaks and choroidal thickness may have the potential to be biomarkers of disease activity in CSC.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.