Abstract
Purpose :
This study aims to analyze research hotspots and trends of stem cells therapy in treating ocular diseases in the past 10 years using bibliometric analysis .
Methods :
The publications on stem cell therapy in ocular diseases were obtained from the Web of Science Core Collection. The search strategy was (TS=(stem cell therapy) AND TS=(ocular diseases OR eye diseases) AND LA=(English) AND DT=(Article OR Review)). A total of 612 publications met our selection criteria, and we used Citespace and VOS Viewer to perform a bibliometric analysis of countries/regions, institutions, journals, authors, references, and keywords based on these articles and reviews.
Results :
In total, 3273 authors from 2202 institutions in 241 countries/regions had published articles in 249 journals in this field, mainly from the USA and China. Sayan Basu published the most papers on stem cell therapy in ocular diseases, while articles from Steven D Schwartz had the most co-citations. According to the reference analysis, most publications focused on cell biology, clinical trials, and tissue engineering. We generated the following clusters in Citespace, including retinal degeneration, cell-based therapy, mesenchymal stem cell, versus-host disease, and recent development. Instead of graft-versus-host disease standing for ocular disease triggered by stem cell therapy, others committed to stem cell therapy in treating ocular diseases, especially for retina and ocular surface diseases. “Mesenchymal stem cell(MSC),” “transplantation,” “retinal pigment epithelium(RPE),” and “macular degeneration” are research hotspots based on the co-occurrence map of keywords. At the same time, keyword bursts indicated that “extracellular vesicles,” “intravitreal injection,” and “glaucoma” have become novel research trends.
Conclusions :
Bibliometric analysis showed that stem cell therapy in ocular diseases has attracted worldwide attention over the past decade. The application of pluripotent stem cells and embryonic stem cells in retinal degeneration, mesenchymal stem cells and limbal stem cells in ocular surface diseases has the highest proportion. However, further research and deeper collaboration are still needed in this field. This bibliometric analysis provides recent hotpots and future trends of stem cell therapy in ocular diseases for researchers.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.