Abstract
Purpose :
Several studies have demonstrated a positive association between Helicobacter pylori(H. pylori) infection and Central serous chorioretinopathy (CSC). On the other hand, the effect of treatment of H. pylori infection on CSC had some inconsistence. We aimed to investigate the association of H. pylori infection and treatment with the occurrence of CSC in Taiwanese population.
Methods :
The study was conducted with National Health Insurance Research Database in Taiwan. We collected patients over 18 years old with or without newly diagnosed peptic ulcer disease or H. pylori between 2009 to 2015 and followed until 2018 for the incidence of CSC. We further divided the H. pylori infection subjects into treated and non-treated group. The distributions of risk factors were analyzed with Chi-Square test for the categorical variables and independent t test for continuous variables. Cox proportional hazards model analyses were performed to determine the hazard ratios (HR) of CSC among the matched groups. P-value < 0.05 was defined as statistically significant.
Results :
A total of 1,012,973 subjects in the non- H. pylori group and 1,012,973 patients in the H. pylori group were enrolled after propensity score matching. The incident rate ratio of CSC in H. pylori group compared to non- H. pylori group was 1.097 with 95% confidential interval (CI) of 1.094-1.100. According to cox proportional hazards model, the risk of CSC was also significant higher in H. pylori group compared to non- H. pylori group. The incident rate ratio of CSC in treated H. pylori group was higher compared to non-treated H. pylori group. (HR: 1.137, 95% CI:1.129-1.145). In cox propotional hazards model, the risk of CSC in non-treated H. pylori group was not significantly higher than non- H. pylori group while the risk of CSC incidence in treated H. pylori group compared to non- H. pylori group was significantly higher.
Conclusions :
The results revealed that H. pylori infection increased the risk of CSC. However, of the H. pylori infection subjects, treatment of H. pylori had even higher risk to develop CSC. Our findings were in line with current studies that H. pylori infection is one of the risk factors of CSC. However, we found that treatment of H. pylori further increased the risk of CSC which was contrary to the results of most of the other research. Additional research is essential to substantiate our findings.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.